P14060 | 3BHS1_HUMAN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01073 | 3Beta_HSD - 3-beta hydroxysteroid dehydrogenase/isomerase family | 7~288 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL24033 |  |
IC50 | = | 8.3 | nM | 400.61 | CC(C)(C)CCNC(=O)[C@H]1CCC2C3CNC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL615301 | single protein format |
| CHEMBL24729 |  |
IC50 | = | 150.0 | nM | 428.66 | CC(C)(C)CC(C)(C)NC(=O)[C@H]1CCC2C3CNC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL615301 | single protein format |
| CHEMBL25516 |  |
Ki | = | 7.8 | nM | 504.76 | CC(C)(C)c1cc(NC(=O)[C@H]2CCC3C4CNC5=CC(=O)CC[C@]5(C)C4CC[C@@]32C)cc(C(C)(C)C)c1 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL280155 |  |
Ki | = | 10.0 | nM | 392.54 | C[C@]12CCC(=O)C=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)Nc1ccccc1 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL297524 |  |
Ki | = | 12.0 | nM | 331.46 | COC(=O)[C@H]1CCC2C3CNC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL25183 |  |
Ki | = | 19.0 | nM | 542.56 | CC1=C2NCC3C(CC[C@@]4(C)C3CC[C@@H]4C(=O)Nc3cc(C(F)(F)F)ccc3C(F)(F)F)[C@@]2(C)CCC1=O | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL24088 |  |
Ki | = | 150.0 | nM | 482.67 | C[C@]12CCC(=O)C=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)NC(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL283123 |  |
Ki | = | 160.0 | nM | 509.13 | CC1=C2NCC3C(CC[C@@]4(C)C3CC[C@@H]4C(=O)N(c3ccc(Cl)cc3)C3CCCC3)[C@@]2(C)CCC1=O | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL3085538 |  |
Ki | = | 180.0 | nM | 451.65 | C[C@]12CC[C@H]3[C@@H](CNC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL24291 |  |
Ki | = | 190.0 | nM | 386.54 | C[C@]12CCC(=O)C=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)N1CCOCC1 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL282037 |  |
Ki | = | 190.0 | nM | 562.98 | C[C@]12CCC(=O)C(Cl)=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)Nc1cc(C(F)(F)F)ccc1C(F)(F)F | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL283430 |  |
Ki | = | 490.0 | nM | 529.55 | C[C@]12CCC(=O)C(Cl)=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)N(c1ccc(Cl)cc1)C1CCCC1 | Homo sapiens | CHEMBL615302 | single protein format |
| CHEMBL412425 |  |
Ki | = | 510.0 | nM | 551.56 | C[C@]12CCC(=O)C=C1NCC1C2CC[C@@]2(C)C1CC[C@@H]2C(=O)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL615302 | single protein format |