P13945 | ADRB3_HUMAN | Beta-3 adrenergic receptor (ADRB3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 54~346 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL723 |  |
IC50 | = | 4.155 | nM | 406.48 | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL293994 |  |
IC50 | = | 20.0 | nM | 592.69 | O=S(=O)(Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1)c1ccc(-c2nc(-c3ccc(F)c(F)c3)cs2)cc1 | Homo sapiens | CHEMBL648171 | cell-based format |
| CHEMBL117405 |  |
IC50 | = | 48.0 | nM | 248.33 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL500 |  |
IC50 | = | 88.0 | nM | 248.33 | CC(C)NCC(O)COc1cccc2[nH]ccc12 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL22375 |  |
IC50 | = | 92.0 | nM | 591.74 | O=c1n(CCCC2CCCC2)nnn1-c1ccc(S(=O)(=O)Nc2ccc(CCNC[C@H](O)c3cccnc3)cc2)cc1 | Homo sapiens | CHEMBL648172 | cell-based format |
| CHEMBL27 |  |
IC50 | = | 132.0 | nM | 259.35 | CC(C)NCC(O)COc1cccc2ccccc12 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL452861 |  |
IC50 | = | 165.0 | nM | 259.35 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL4285281 |  |
IC50 | = | 240.0 | nM | 297.35 | COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2 | Homo sapiens | CHEMBL4258828 | single protein format |
| CHEMBL1201237 |  |
IC50 | = | 340.0 | nM | 291.39 | CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL631 |  |
IC50 | = | 424.0 | nM | 341.45 | CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL499 |  |
IC50 | = | 452.0 | nM | 316.43 | CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL357995 |  |
IC50 | = | 458.0 | nM | 380.49 | Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 | Homo sapiens | CHEMBL1909093 | cell membrane format |
| CHEMBL486327 |  |
IC50 | = | 550.0 | nM | 462.59 | COc1ccc(CNCC(O)COc2ccc3c(c2)CCCN3Cc2ccccc2)cc1OC | Homo sapiens | CHEMBL938627 | single protein format |
| CHEMBL458541 |  |
IC50 | = | 590.0 | nM | 354.49 | CC(C)NCC(O)COc1ccc2c(c1)CCCN2Cc1ccccc1 | Homo sapiens | CHEMBL938627 | single protein format |
| CHEMBL1257675 |  |
Ki | = | 1.0 | nM | 520.66 | COCc1cc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)ccc1O | Homo sapiens | CHEMBL1261324 | cell-based format |
| CHEMBL442225 |  |
Ki | = | 1.1 | nM | 542.68 | C[C@H](Cc1c[nH]c2c(S(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NS(=O)(=O)c2cccc(N)c2)c1 | Homo sapiens | CHEMBL839161 | single protein format |
| CHEMBL105758 |  |
Ki | = | 2.0 | nM | 542.6 | CS(=O)(=O)Nc1cc([C@@H](O)CN[C@H](Cc2ccccc2)c2ccc(OC(F)F)c3ccccc23)ccc1O | Homo sapiens | CHEMBL652054 | cell-based format |
| CHEMBL186247 |  |
Ki | = | 2.6 | nM | 528.66 | CS(=O)(=O)c1cccc2c(CCNC[C@H](O)c3cccc(NS(=O)(=O)c4cccc(N)c4)c3)c[nH]c12 | Homo sapiens | CHEMBL839161 | single protein format |
| CHEMBL250978 |  |
Ki | = | 3.0 | nM | 528.63 | COc1ccc([C@@H](Cc2ccccc2)NC[C@H](O)CC(=O)c2ccc(O)c(NS(C)(=O)=O)c2)cc1OC | Homo sapiens | CHEMBL888301 | cell-based format |
| CHEMBL723 | |
Ki | = | 3.116 | nM | 406.48 | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL1909093 | cell membrane format |