P13866 | SC5A1_HUMAN | Sodium/glucose cotransporter 1 (SLC5A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00474 | SSF - Sodium:solute symporter family | 58~492 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL485830 |  |
IC50 | = | 0.16 | nM | 330.34 | NC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O | Homo sapiens | CHEMBL974294 | assay format |
| CHEMBL521026 |  |
IC50 | = | 0.17 | nM | 372.38 | CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)O | Homo sapiens | CHEMBL974294 | assay format |
| CHEMBL4297625 |  |
IC50 | = | 0.5 | nM | 416.47 | CCc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc2c(c1)OCCO2 | Homo sapiens | CHEMBL4727638 | single protein format |
| CHEMBL3690855 |  |
IC50 | = | 0.7 | nM | 450.97 | C[C@H]1C(=O)NC[C@@H]1C(=O)Nc1cc(-c2cccc(C(C)(C)C)c2)n(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686477 |  |
IC50 | = | 0.9 | nM | 436.94 | CC(C)(C)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)C3)nn2-c2ccccc2Cl)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3695107 |  |
IC50 | = | 1.1 | nM | 534.51 | CCOc1ccc(F)c(-n2nc(NC(=O)[C@@H]3CNC(=O)C3)cc2-c2cccc(CO[C@H](C)C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686485 |  |
IC50 | = | 1.1 | nM | 458.9 | CCC(F)(F)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)C3)nn2-c2ccccc2Cl)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690821 |  |
IC50 | = | 1.1 | nM | 438.48 | CCC(F)(F)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)[C@@H]3C)nn2-c2ccccc2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686471 |  |
IC50 | = | 1.2 | nM | 436.94 | CC(C)(C)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)C3)nn2-c2cccc(Cl)c2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686475 |  |
IC50 | = | 1.3 | nM | 464.83 | O=C1C[C@@H](C(=O)Nc2cc(-c3cccc(OC(F)(F)F)c3)n(-c3ccccc3Cl)n2)CN1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686489 |  |
IC50 | = | 1.3 | nM | 438.48 | CCC(F)(F)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)C3)nn2-c2ccccc2C)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690868 |  |
IC50 | = | 1.3 | nM | 472.92 | CCC(F)(F)c1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)[C@@H]3C)nn2-c2ccccc2Cl)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690854 |  |
IC50 | = | 1.3 | nM | 478.86 | C[C@H]1C(=O)NC[C@@H]1C(=O)Nc1cc(-c2cccc(OC(F)(F)F)c2)n(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686463 |  |
IC50 | = | 1.4 | nM | 406.46 | CCCc1cccc(-c2cc(NC(=O)[C@H]3CNC(=O)C3)nn2-c2ccccc2F)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690863 |  |
IC50 | = | 1.4 | nM | 462.86 | C[C@H]1C(=O)NC[C@@H]1C(=O)Nc1cc(-c2cccc(C(F)(F)F)c2)n(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3695105 |  |
IC50 | = | 1.4 | nM | 534.51 | CC(C)Oc1ccc(F)c(-n2nc(NC(=O)[C@@H]3CNC(=O)C3)cc2-c2cccc(COCC(F)(F)F)c2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3695108 |  |
IC50 | = | 1.4 | nM | 548.54 | CC(C)Oc1ccc(F)c(-n2nc(NC(=O)[C@@H]3CNC(=O)C3)cc2-c2cccc(CO[C@H](C)C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3686472 |  |
IC50 | = | 1.4 | nM | 416.53 | Cc1cccc(-n2nc(NC(=O)[C@H]3CNC(=O)C3)cc2-c2cccc(C(C)(C)C)c2)c1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690875 |  |
IC50 | = | 1.4 | nM | 492.89 | C[C@H]1C(=O)NC[C@@H]1C(=O)Nc1cc(-c2cccc(OCC(F)(F)F)c2)n(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL3705647 | assay format |
| CHEMBL3690942 |  |
IC50 | = | 1.5 | nM | 437.57 | CCCc1cccc(-c2cc(NC(=O)C3CCS(=O)(=O)CC3)nn2-c2ccccc2)c1 | Homo sapiens | CHEMBL3705647 | assay format |