P13674 | P4HA1_HUMAN | Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF08336 | P4Ha_N - Prolyl 4-Hydroxylase alpha-subunit, N-terminal region | 24~155 | |
| PF13640 | 2OG-FeII_Oxy_3 - 2OG-Fe(II) oxygenase superfamily | 415~518 | |
| PF23558 | TPR_P4H - Prolyl 4-hydroxylase peptide-substrate-binding domain | 164~254 |
3D structures mapped by conservation among orthologs
[ Domain: "Prolyl 4-hydroxylase alpha subunit dimerization domain" // P4Ha_N ]
[ Domain: "Prolyl 4-hydroxylase alpha subunit dimerization domain" // P4Ha_N ]
[ Domain: "ARM repeat" // Fis1_TPR_C_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL332005 |  |
IC50 | = | 840.0 | nM | 244.21 | O=C(O)c1ccc(-c2ccc(C(=O)O)cn2)nc1 | Homo sapiens | CHEMBL3587049 | assay format |
| CHEMBL332005 | |
Ki | = | 140.0 | nM | 244.21 | O=C(O)c1ccc(-c2ccc(C(=O)O)cn2)nc1 | Homo sapiens | CHEMBL3587050 | assay format |
| CHEMBL3586252 |  |
Ki | = | 200.0 | nM | 244.21 | O=C(O)c1ccc(-c2cc(C(=O)O)ccn2)nc1 | Homo sapiens | CHEMBL3587050 | assay format |