P13631 | RARG_HUMAN | Retinoic acid receptor gamma (RARG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 228~398 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 89~157 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL38 |  |
IC50 | = | 0.62 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL806262 | single protein format |
| CHEMBL131850 |  |
IC50 | = | 2.0 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)cs3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL336311 |  |
IC50 | = | 3.6 | nM | 393.51 | CC1(C)CCC(C)(C)c2nc(-c3csc(-c4ccc(C(=O)O)cc4)n3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL132033 |  |
IC50 | = | 4.6 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)o3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL131810 |  |
IC50 | = | 17.0 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)s3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL705 |  |
IC50 | = | 17.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL877733 | single protein format |
| CHEMBL134375 |  |
IC50 | = | 21.0 | nM | 373.5 | CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)ccc21 | Homo sapiens | CHEMBL800488 | single protein format |
| CHEMBL275311 |  |
IC50 | = | 26.0 | nM | 348.49 | C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL877733 | single protein format |
| CHEMBL131925 |  |
IC50 | = | 27.0 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)co3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL550796 |  |
IC50 | = | 40.0 | nM | 380.48 | CC(=C\c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C)/C=C(\C)C(=O)O | Homo sapiens | CHEMBL1063215 | single protein format |
| CHEMBL337003 |  |
IC50 | = | 150.0 | nM | 375.47 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)c[nH]3)cnc21 | Homo sapiens | CHEMBL800489 | single protein format |
| CHEMBL284937 |  |
IC50 | = | 250.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL877733 | single protein format |
| CHEMBL133725 |  |
IC50 | = | 310.0 | nM | 375.47 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)cnc21 | Homo sapiens | CHEMBL800490 | single protein format |
| CHEMBL32505 |  |
IC50 | = | 645.0 | nM | 362.51 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL877733 | single protein format |
| CHEMBL3894222 |  |
IC50 | = | 800.0 | nM | 417.22 | O=C(O)c1ccc(-n2nc(Oc3c(Cl)cccc3Cl)c3c(F)cccc32)cc1 | Homo sapiens | CHEMBL3868204 | cell-based format |
| CHEMBL38 | |
Ki | = | 0.7 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL806272 | single protein format |
| CHEMBL36768 |  |
Ki | = | 2.0 | nM | 358.48 | CC1(C)CCC(C)(C)c2cc3cc(-c4ccc(C(=O)O)cc4)ccc3cc21 | Homo sapiens | CHEMBL798022 | single protein format |
| CHEMBL275311 | |
Ki | = | 5.0 | nM | 348.49 | C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798022 | single protein format |
| CHEMBL74826 |  |
Ki | = | 13.0 | nM | 324.42 | COc1ccc(/C(C)=C/c2ccc(C(=O)O)cc2)cc1C(C)(C)C | Homo sapiens | CHEMBL798022 | single protein format |
| CHEMBL75848 |  |
Ki | = | 19.0 | nM | 362.47 | CC1(C)CCC(C)(C)c2cc(C3=Cc4ccc(C(=O)O)cc4OC3)ccc21 | Homo sapiens | CHEMBL798023 | single protein format |