ProtHub

P13612 | ITA4_HUMAN | Integrin alpha-4 (ITGA4)

Pfam Domain Table

Accession	Domain	Range
PF01839	FG-GAP - FG-GAP repeat	306~342
PF01839	FG-GAP - FG-GAP repeat	368~403
PF08441	Integrin_A_Ig_1 - Integrin alpha Ig-like domain 1	463~620
PF20805	Integrin_A_Ig_2 - Integrin alpha Ig-like domain 2	622~769
PF20806	Integrin_A_Ig_3 - Integrin alpha Ig-like domain 3	776~947

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Integrin_alpha2_1st ]

3V4P
3V4V

PyMOL session

[ Domain: "7-bladed" // FG-GAP_1st ]

3V4P
3V4V

PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL278199	IC50	=	0.5	nM	524.67	N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)C2(CCCC2)CCNC1=O	Homo sapiens	CHEMBL820787	single protein format
CHEMBL425647	IC50	=	0.51	nM	539.99	Cc1ccccc1NC(=O)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL29359	IC50	=	0.64	nM	577.49	COc1ccccc1-c1ccc(C[C@H](NC(=O)[C@@H]2CCCN2S(=O)(=O)c2cc(Cl)cc(Cl)c2)C(=O)O)cc1	Homo sapiens	CHEMBL949077	cell-based format
CHEMBL16710	IC50	=	0.7	nM	566.7	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)C2(CCCC2)CCNC1=O	Homo sapiens	CHEMBL820787	single protein format
CHEMBL426910	IC50	=	0.78	nM	584.44	Cc1ccccc1NC(=O)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Br	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL390057	IC50	=	0.87	nM	555.99	COc1cc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)ccc1NC(=O)Nc1ccccc1Cl	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL389844	IC50	=	1.2	nM	535.57	COc1cc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)ccc1NC(=O)Nc1ccccc1C	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL387659	IC50	=	1.3	nM	560.41	O=C(Nc1ccccc1Cl)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL347903	IC50	=	1.4	nM	471.36	O=C(O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1cc(Cl)cc(Cl)c1	Homo sapiens	CHEMBL949077	cell-based format
CHEMBL457223	IC50	=	1.6	nM	557.98	Cc1ccc(F)cc1NC(=O)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL456815	IC50	=	1.8	nM	557.98	Cc1ccccc1NC(=O)Nc1cc(F)c(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL515662	IC50	=	1.9	nM	554.02	Cc1cc(NC(=O)Nc2ccccc2C)c(Cl)cc1CC(=O)N1C[C@@H](F)C[C@H]1COc1ccc(C(=O)O)cc1	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL456814	IC50	=	2.2	nM	574.44	Cc1ccccc1NC(=O)Nc1cc(Cl)c(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL426908	IC50	=	2.3	nM	519.57	Cc1ccccc1NC(=O)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1C	Homo sapiens	CHEMBL903783	cell-based format
CHEMBL481501	IC50	=	2.8	nM	509.58	Cc1ccccc1Nc1nc2ccc(CC(=O)N3C[C@@H](F)C[C@H]3CO[C@H]3CC[C@H](C(=O)O)CC3)cc2o1	Homo sapiens	CHEMBL1023759	cell-based format
CHEMBL515348	IC50	=	2.8	nM	557.98	Cc1cc(F)ccc1NC(=O)Nc1ccc(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL456180	IC50	=	2.9	nM	578.4	O=C(Nc1ccccc1Cl)Nc1cc(F)c(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL456399	IC50	=	3.4	nM	594.85	O=C(Nc1ccccc1Cl)Nc1cc(Cl)c(CC(=O)N2C[C@@H](F)C[C@H]2COc2ccc(C(=O)O)cc2)cc1Cl	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL456608	IC50	=	3.5	nM	574.44	Cc1cc(NC(=O)Nc2ccccc2Cl)c(Cl)cc1CC(=O)N1C[C@@H](F)C[C@H]1COc1ccc(C(=O)O)cc1	Homo sapiens	CHEMBL987226	cell-based format
CHEMBL276353	IC50	=	3.9	nM	526.68	CCC1(CC)CCNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC1=O	Homo sapiens	CHEMBL820787	single protein format