P12931 | SRC_HUMAN | Proto-oncogene tyrosine-protein kinase Src (SRC)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 151~233 | |
| PF00018 | SH3_1 - SH3 domain | 90~137 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 271~518 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1241676 |  |
IC50 | = | 0.12 | nM | 329.79 | Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2C1CCCC1 | Homo sapiens | CHEMBL1243974 | single protein format |
| CHEMBL5095061 |  |
IC50 | = | 0.12 | nM | 409.43 | CCN1Cc2c(ccc(F)c2C#N)O[C@@H](C)CNC(=O)c2c(N)nn3ccc1nc23 | Homo sapiens | CHEMBL5356792 | single protein format |
| CHEMBL196797 |  |
IC50 | = | 0.15 | nM | 533.03 | COc1cc(Nc2c(C#N)cnc3cc4cc(OCCN5CCOCC5)c(OC)cc4cc23)c(C)cc1Cl | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL3976548 |  |
IC50 | = | 0.18 | nM | 352.78 | Nc1c(C(=O)c2cc3ccccc3[nH]2)cnn1-c1cc(O)ccc1Cl | Homo sapiens | CHEMBL3861875 | single protein format |
| CHEMBL3216659 |  |
IC50 | = | 0.2 | nM | 541.28 | Cl.Cl.O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 | Homo sapiens | CHEMBL5347078 | single protein format |
| CHEMBL281957 |  |
IC50 | = | 0.2 | nM | 484.43 | CCN(CC)C/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C | Homo sapiens | CHEMBL808766 | single protein format |
| CHEMBL425389 |  |
IC50 | = | 0.22 | nM | 544.61 | COc1cc2cc3c(Nc4cc(OC)c(OC)c(OC)c4)c(C#N)cnc3cc2cc1OCCN1CCOCC1 | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL454358 |  |
IC50 | < | 0.23 | nM | 502.56 | Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(N3CCOCC3)nc21 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL509941 |  |
IC50 | < | 0.23 | nM | 515.6 | Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(N3CCN(C)CC3)nc21 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL198650 |  |
IC50 | = | 0.29 | nM | 566.49 | COc1cc(Nc2c(C#N)cnc3cc4cc(OCCN5CCN(C)CC5)c(OC)cc4cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL196889 |  |
IC50 | = | 0.31 | nM | 546.07 | COc1cc(Nc2c(C#N)cnc3cc4cc(OCCN5CCN(C)CC5)c(OC)cc4cc23)c(C)cc1Cl | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL370633 |  |
IC50 | = | 0.33 | nM | 533.03 | COc1cc(Nc2c(C#N)cnc3cc4cc(OCCN5CCOCC5)c(OC)cc4cc23)c(Cl)cc1C | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL3984621 |  |
IC50 | = | 0.43 | nM | 451.91 | Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl | Homo sapiens | CHEMBL3861875 | single protein format |
| CHEMBL1089405 |  |
IC50 | = | 0.45 | nM | 475.53 | CP(C)(=O)c1ccc(Nc2nc(C3CCCC3)nc3c2ncn3CCc2cccc(O)c2)cc1 | Homo sapiens | CHEMBL1114553 | single protein format |
| CHEMBL195029 |  |
IC50 | = | 0.46 | nM | 553.45 | COc1cc(Nc2c(C#N)cnc3cc4cc(OCCN5CCOCC5)c(OC)cc4cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL881508 | single protein format |
| CHEMBL509002 |  |
IC50 | < | 0.46 | nM | 447.48 | COc1nc(Nc2ccc(P(C)(C)=O)cc2)c2ncn(/C=C/c3c(C)cccc3C)c2n1 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL455384 |  |
IC50 | < | 0.46 | nM | 483.52 | Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(-n3ccnc3)nc21 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL510893 |  |
IC50 | < | 0.46 | nM | 443.45 | Cc1ccc2[nH]ncc2c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL461767 |  |
IC50 | < | 0.46 | nM | 491.53 | COCCOc1nc(Nc2ccc(P(C)(C)=O)cc2)c2ncn(/C=C/c3c(C)cccc3C)c2n1 | Homo sapiens | CHEMBL976274 | single protein format |
| CHEMBL461768 |  |
IC50 | < | 0.46 | nM | 514.61 | Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(C3CCN(C)CC3)nc21 | Homo sapiens | CHEMBL976274 | single protein format |