P12081 | HARS1_HUMAN | Histidine--tRNA ligase, cytoplasmic (HARS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00458 | WHEP-TRS - WHEP-TRS domain | 7~45 | |
| PF03129 | HGTP_anticodon - Anticodon binding domain | 410~500 | |
| PF13393 | tRNA-synt_His - Histidyl-tRNA synthetase | 61~389 |
3D structures mapped by conservation among orthologs
[ Domain: "S15/NS1 RNA-binding domain" // WHEP-TRS ]
[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_His ]
[ Domain: "Anticodon-binding domain of Class II aaRS" // HGTP_anticodon ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL412891 |  |
IC50 | = | 130.0 | nM | 483.47 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL694931 | single protein format |