P12081 | HARS1_HUMAN | Histidine--tRNA ligase, cytoplasmic (HARS1)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00458WHEP-TRS7–45
PF03129HGTP_anticodon410–500
PF13393tRNA-synt_His61–389

 3D structures mapped by conservation among orthologs

[ Domain: "S15/NS1 RNA-binding domain" // WHEP-TRS ]

 PyMOL session

[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_His ]

 PyMOL session

[ Domain: "Anticodon-binding domain of Class II aaRS" // HGTP_anticodon ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL412891 IC50 = 130.0 nM 483.47 Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](O)[C@H]1O Homo sapiens CHEMBL694931 single protein format