P11802 | CDK4_HUMAN | Cyclin-dependent kinase 4 (CDK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 6~295 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL334285 |  |
IC50 | = | 0.007 | nM | 507.58 | O=C(Nc1cccc2c1C(=O)c1c(-c3ccc(C(=O)N4CCNCC4)s3)n[nH]c1-2)NN1CCOCC1 | Homo sapiens | CHEMBL4407028 | single protein format |
| CHEMBL151546 |  |
IC50 | = | 0.026 | nM | 344.78 | NC(=O)Nc1cccc2c1C(=O)c1c(-c3csc(Cl)c3)n[nH]c1-2 | Homo sapiens | CHEMBL4407028 | single protein format |
| CHEMBL148580 |  |
IC50 | = | 0.08 | nM | 459.51 | COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)CN4CCN(C(=N)N)CC4)cccc2-3)cc1 | Homo sapiens | CHEMBL4407028 | single protein format |
| CHEMBL3698644 |  |
IC50 | = | 0.13 | nM | 415.51 | c1cc2c3cnc(Nc4cnc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL4453997 |  |
IC50 | = | 0.2 | nM | 304.31 | COc1ccc(-c2n[nH]c3c2C(=O)c2c(C=O)cccc2-3)cc1 | Homo sapiens | CHEMBL4407028 | single protein format |
| CHEMBL526110 |  |
IC50 | = | 0.3 | nM | 333.31 | O=[N+]([O-])c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 | Homo sapiens | CHEMBL1002018 | single protein format |
| CHEMBL3698653 |  |
IC50 | = | 0.32 | nM | 421.51 | c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)cc1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3698639 |  |
IC50 | = | 0.45 | nM | 413.53 | c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CCCC3)c2cn1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL4209329 |  |
IC50 | = | 0.6 | nM | 490.56 | CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCNCC6)cn5)ncc4F)cc3n21 | Homo sapiens | CHEMBL4188521 | single protein format |
| CHEMBL4211828 |  |
IC50 | = | 0.6 | nM | 518.62 | CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 | Homo sapiens | CHEMBL4188521 | single protein format |
| CHEMBL4215702 |  |
IC50 | = | 0.8 | nM | 504.59 | CN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 | Homo sapiens | CHEMBL4188521 | single protein format |
| CHEMBL3698671 |  |
IC50 | = | 0.83 | nM | 413.53 | c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3698641 |  |
IC50 | = | 0.91 | nM | 428.54 | Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3698659 |  |
IC50 | = | 0.94 | nM | 440.56 | c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CC4CCC3C4)c2cn1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3698688 |  |
IC50 | = | 0.97 | nM | 456.6 | CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3702060 |  |
IC50 | = | 1.0 | nM | 491.04 | CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL3904602 |  |
IC50 | = | 1.0 | nM | 474.61 | CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 | Homo sapiens | CHEMBL5230718 | single protein format |
| CHEMBL3702122 |  |
IC50 | = | 1.0 | nM | 486.58 | O=C(O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 | Homo sapiens | CHEMBL3705960 | single protein format |
| CHEMBL4205645 |  |
IC50 | = | 1.0 | nM | 500.63 | CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 | Homo sapiens | CHEMBL4188521 | single protein format |
| CHEMBL3698649 |  |
IC50 | = | 1.0 | nM | 457.59 | CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 | Homo sapiens | CHEMBL3705960 | single protein format |