P11766 | ADHX_HUMAN | Alcohol dehydrogenase class-3 (ADH5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00107 | ADH_zinc_N - Zinc-binding dehydrogenase | 202~331 | |
| PF08240 | ADH_N - Alcohol dehydrogenase GroES-like domain | 32~160 |
3D structures mapped by conservation among orthologs
[ Domain: "Alcohol dehydrogenase-like, N-terminal domain" // ADH_N ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // ADH_zinc_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4291042 |  |
IC50 | = | 6.1 | nM | 316.37 | CCc1cc(-n2ccnc2)ccc1-c1ccc(-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL4290485 |  |
IC50 | = | 9.2 | nM | 322.76 | Clc1cc(-c2nnn[nH]2)ccc1-c1ccc(-n2ccnc2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL3661058 |  |
IC50 | = | 11.0 | nM | 431.45 | CCOc1cc([C@@H]2NC(=O)N=C(c3ccccc3)C2c2ccccc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3705329 | single protein format |
| CHEMBL4289979 |  |
IC50 | = | 11.0 | nM | 334.36 | CCc1cc(-n2ccnc2)ccc1-c1ccc(-c2nnn[nH]2)cc1F | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL3650413 |  |
IC50 | = | 11.0 | nM | 431.45 | CCOc1cc([C@@H]2NC(=O)NC(c3ccccc3)=C2c2ccccc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3706121 | cell-based format |
| CHEMBL4294439 |  |
IC50 | = | 12.0 | nM | 336.79 | Cc1cc(-n2ccnc2)ccc1-c1ccc(-c2nnn[nH]2)cc1Cl | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL3650428 |  |
IC50 | = | 13.0 | nM | 442.5 | CCOc1cc(C2NC(=O)NC(c3cnn(C)c3)C2c2ccsc2)cc(C(=O)O)c1O | Homo sapiens | CHEMBL3706121 | cell-based format |
| CHEMBL3661051 |  |
IC50 | = | 13.0 | nM | 440.48 | CCOc1cc([C@@H]2NC(=O)N=C(c3cnn(C)c3)C2c2ccsc2)cc(C(=O)O)c1O | Homo sapiens | CHEMBL3705329 | single protein format |
| CHEMBL4289333 |  |
IC50 | = | 14.0 | nM | 321.32 | Cc1cc(-n2ccnc2)cnc1-c1ccc(-c2nnn[nH]2)cc1F | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL4283184 |  |
IC50 | = | 14.0 | nM | 302.34 | Cc1cc(-n2ccnc2)ccc1-c1ccc(-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL3650426 |  |
IC50 | = | 16.0 | nM | 438.47 | CCOc1cc([C@@H]2NC(=O)NC(c3cccnc3)=C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3706121 | cell-based format |
| CHEMBL3661050 |  |
IC50 | = | 16.0 | nM | 438.47 | CCOc1cc(C2=NC(=O)NC(c3cccnc3)C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3705329 | single protein format |
| CHEMBL4286132 |  |
IC50 | = | 17.0 | nM | 303.33 | Cc1cc(-n2ccnc2)cnc1-c1ccc(-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL3661059 |  |
IC50 | = | 18.0 | nM | 437.48 | CCOc1cc([C@@H]2NC(=O)N=C(c3ccccc3)C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3705329 | single protein format |
| CHEMBL3650415 |  |
IC50 | = | 18.0 | nM | 437.48 | CCOc1cc([C@@H]2NC(=O)NC(c3ccccc3)=C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3706121 | cell-based format |
| CHEMBL3650420 |  |
IC50 | = | 19.0 | nM | 437.48 | CCOc1cc(C2NC(=O)NC(c3ccccc3)=C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3706121 | cell-based format |
| CHEMBL3661042 |  |
IC50 | = | 19.0 | nM | 437.48 | CCOc1cc(C2NC(=O)N=C(c3ccccc3)C2c2ccsc2)cc([N+](=O)[O-])c1O | Homo sapiens | CHEMBL3705329 | single protein format |
| CHEMBL1738699 |  |
IC50 | = | 20.0 | nM | 414.47 | Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)O)ccc1-c1ccc(-n2ccnc2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL4283157 |  |
IC50 | = | 20.0 | nM | 278.31 | Cc1cc(-n2ccnc2)ccc1-c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |
| CHEMBL4287066 |  |
IC50 | = | 20.0 | nM | 306.3 | Fc1cc(-c2nnn[nH]2)ccc1-c1ccc(-n2ccnc2)cc1 | Homo sapiens | CHEMBL4260538 | single protein format |