P11712 | CP2C9_HUMAN | Cytochrome P450 2C9 (CYP2C9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 30~487 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388590 |  |
IC50 | = | 16.0 | nM | 424.09 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL104 |  |
IC50 | = | 16.0 | nM | 344.85 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL3898132 |  |
IC50 | = | 30.0 | nM | 453.35 | Cn1cc(-c2nc3c(N4CCN(Cc5cccnc5)CC4)c(Br)cnc3[nH]2)cn1 | Homo sapiens | CHEMBL3889069 | single protein format |
| CHEMBL3645225 |  |
IC50 | = | 30.0 | nM | 347.41 | CNC(=O)/C=C/c1cc(OC)cc(-c2ccc3cc(OC)ccc3c2)c1 | Homo sapiens | CHEMBL3707849 | single protein format |
| CHEMBL2207500 |  |
IC50 | = | 30.0 | nM | 413.87 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ncon4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889069 | single protein format |
| CHEMBL3891461 |  |
IC50 | = | 30.0 | nM | 481.4 | Cc1nn(C)c(C)c1-c1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1 | Homo sapiens | CHEMBL3889069 | single protein format |
| CHEMBL2207501 |  |
IC50 | = | 30.0 | nM | 427.9 | Cc1nc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cn(C)nc5C)nc34)CC2)no1 | Homo sapiens | CHEMBL3889069 | single protein format |
| CHEMBL2207503 |  |
IC50 | = | 30.0 | nM | 456.38 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889069 | single protein format |
| CHEMBL3645217 |  |
IC50 | = | 150.0 | nM | 427.46 | O=C(O)CCC(=O)Nc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cc1 | Homo sapiens | CHEMBL3707849 | single protein format |
| CHEMBL91 |  |
IC50 | = | 200.0 | nM | 416.13 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL1221 |  |
IC50 | = | 200.0 | nM | 397.76 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL808 |  |
IC50 | = | 200.0 | nM | 381.69 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL1109 |  |
IC50 | = | 200.0 | nM | 314.37 | Nc1ccc(S(=O)(=O)Nc2ccnn2-c2ccccc2)cc1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL1650646 |  |
IC50 | = | 224.0 | nM | 343.38 | COc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cn1 | Homo sapiens | CHEMBL3707849 | single protein format |
| CHEMBL475534 |  |
IC50 | = | 300.0 | nM | 360.37 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL1466 |  |
IC50 | = | 300.0 | nM | 336.3 | O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL1479 |  |
IC50 | = | 300.0 | nM | 337.46 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL3969750 |  |
IC50 | = | 400.0 | nM | 553.63 | CNC(C)C(=O)Nc1ccc(-c2c(-c3ccncc3)nc3cc(C)ccn23)c(C#Cc2ccc(-c3ccon3)cc2)n1 | Homo sapiens | CHEMBL3889226 | tissue-based format |
| CHEMBL2220442 |  |
IC50 | = | 400.0 | nM | 411.47 | CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 | Homo sapiens | CHEMBL1909135 | cell-based format |
| CHEMBL3910478 |  |
IC50 | = | 400.0 | nM | 551.65 | CNC(C)C(=O)Nc1ccc(-c2c(-c3ccncc3)nc3cc(C)ccn23)c(C#Cc2ccc3nc(C)ccc3c2)n1 | Homo sapiens | CHEMBL3889226 | tissue-based format |