P11597 | CETP_HUMAN | Cholesteryl ester transfer protein (CETP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01273 | LBP_BPI_CETP - LBP / BPI / CETP family, N-terminal domain | 36~208 | |
| PF02886 | LBP_BPI_CETP_C - LBP / BPI / CETP family, C-terminal domain | 245~478 |
3D structures mapped by conservation among orthologs
[ Domain: "Aha1/BPI domain-like" // LBP_BPI_CETP ]
[ Domain: "Aha1/BPI domain-like" // LBP_BPI_CETP_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL67129 |  |
IC50 | = | 0.77 | nM | 565.91 | CCc1cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)C[C@@H](O)C(F)(F)F)c2)ccc1Cl | Homo sapiens | CHEMBL815633 | single protein format |
| CHEMBL2152167 |  |
IC50 | = | 1.0 | nM | 589.94 | O=C(N[C@@H]1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL3813720 |  |
IC50 | = | 1.5 | nM | 568.89 | OC(CN[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)CC(F)(F)F | Homo sapiens | CHEMBL3815811 | single protein format |
| CHEMBL3813836 |  |
IC50 | = | 1.8 | nM | 595.5 | CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@@H](O)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F | Homo sapiens | CHEMBL3815811 | single protein format |
| CHEMBL2152180 |  |
IC50 | = | 2.0 | nM | 581.89 | O=C(NCCC(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL3814418 |  |
IC50 | = | 2.9 | nM | 595.5 | CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@H](O)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F | Homo sapiens | CHEMBL3815811 | single protein format |
| CHEMBL2152183 |  |
IC50 | = | 3.0 | nM | 567.86 | O=C(NCC(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL2152166 |  |
IC50 | = | 5.0 | nM | 589.94 | O=C(NC1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL2152158 |  |
IC50 | = | 6.0 | nM | 541.92 | O=C(NC1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL2152165 |  |
IC50 | = | 6.0 | nM | 553.96 | O=C(NC1CCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL2152170 |  |
IC50 | = | 7.0 | nM | 575.91 | O=C(NC1CC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL2152168 |  |
IC50 | = | 7.0 | nM | 589.94 | O=C(N[C@H]1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL4114495 |  |
IC50 | = | 7.5 | nM | 562.46 | O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)CC1c1cccc(OC(F)F)c1)C(F)(F)F | Homo sapiens | CHEMBL3887234 | cell-free format |
| CHEMBL3982660 |  |
IC50 | = | 8.0 | nM | 500.48 | O[C@H](CN1c2ccccc2N(CC2=CCCCC2)C[C@H]1c1cccc(OC(F)(F)F)c1)C(F)(F)F | Homo sapiens | CHEMBL3887233 | single protein format |
| CHEMBL2152179 |  |
IC50 | = | 8.0 | nM | 527.92 | CCCNC(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |
| CHEMBL3814359 |  |
IC50 | = | 9.0 | nM | 520.88 | OC(CN[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)CC(F)(F)F | Homo sapiens | CHEMBL3815811 | single protein format |
| CHEMBL3679155 |  |
IC50 | = | 9.0 | nM | 568.89 | O[C@H](CNCC(Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F | Homo sapiens | CHEMBL3705578 | single protein format |
| CHEMBL3683926 |  |
IC50 | = | 9.0 | nM | 581.48 | Cc1ccc(CC(CNC[C@@H](O)C(F)(F)F)(c2cccc(OC(F)(F)F)c2)c2cccc(OC(F)(F)F)c2)cc1 | Homo sapiens | CHEMBL3705578 | single protein format |
| CHEMBL3894287 |  |
IC50 | = | 9.0 | nM | 489.53 | CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](O)CC1(CC1)[C@H]2O | Homo sapiens | CHEMBL3887332 | cell-based format |
| CHEMBL2152169 |  |
IC50 | = | 10.0 | nM | 561.89 | O=C(NC1CC1(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 | Homo sapiens | CHEMBL2155542 | single protein format |