P11586 | C1TC_HUMAN | C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00763 | THF_DHG_CYH - Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | 7~125 | |
| PF01268 | FTHFS - Formate--tetrahydrofolate ligase | 318~935 | |
| PF02882 | THF_DHG_CYH_C - Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | 129~293 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // THF_DHG_CYH_C ]
[ Domain: "Aminoacid dehydrogenase-like, N-terminal domain" // THF_DHG_CYH ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1233930 |  |
IC50 | = | 96.0 | nM | 471.43 | Nc1nc(O)c2c(n1)NC[C@@H]1CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)C(=O)N21 | Homo sapiens | CHEMBL4434261 | assay format |