P11509 | CP2A6_HUMAN | Cytochrome P450 2A6 (CYP2A6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 34~490 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3640770 |  |
IC50 | = | 20.0 | nM | 177.25 | CCC1CCC(c2cccnc2)O1 | Homo sapiens | CHEMBL3705713 | single protein format |
| CHEMBL1770735 |  |
IC50 | = | 100.0 | nM | 163.24 | NCc1cc2ccccc2s1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL359657 |  |
IC50 | = | 160.0 | nM | 190.27 | NCc1ccc(-c2cccnc2)s1 | Homo sapiens | CHEMBL3706122 | assay format |
| CHEMBL441367 |  |
IC50 | = | 160.0 | nM | 192.65 | Clc1ccc(Cn2ccnc2)cc1 | Homo sapiens | CHEMBL3706122 | assay format |
| CHEMBL178090 |  |
IC50 | = | 200.0 | nM | 174.2 | NCc1ccc(-c2cccnc2)o1 | Homo sapiens | CHEMBL3706122 | assay format |
| CHEMBL179669 |  |
IC50 | = | 200.0 | nM | 175.26 | Cc1ccsc1-c1cccnc1 | Homo sapiens | CHEMBL3706122 | assay format |
| CHEMBL3358192 |  |
IC50 | = | 300.0 | nM | 163.2 | O=Cc1cc2cnccc2s1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL3640764 |  |
IC50 | = | 330.0 | nM | 178.24 | NCC1CCC(c2cccnc2)O1 | Homo sapiens | CHEMBL3705713 | single protein format |
| CHEMBL4443442 |  |
IC50 | = | 330.0 | nM | 178.24 | NC[C@@H]1CC[C@@H](c2cccnc2)O1 | Homo sapiens | CHEMBL4422404 | microsome format |
| CHEMBL3640765 |  |
IC50 | = | 360.0 | nM | 242.12 | BrCC1CCC(c2cccnc2)O1 | Homo sapiens | CHEMBL3705713 | single protein format |
| CHEMBL179477 |  |
IC50 | = | 360.0 | nM | 145.16 | c1cncc(-n2ccnc2)c1 | Homo sapiens | CHEMBL3705713 | single protein format |
| CHEMBL178781 |  |
IC50 | = | 360.0 | nM | 159.19 | Cc1cn(-c2cccnc2)cn1 | Homo sapiens | CHEMBL4422404 | microsome format |
| CHEMBL3358207 |  |
IC50 | = | 400.0 | nM | 163.2 | O=Cc1cc2cccnc2s1 | Homo sapiens | CHEMBL3390303 | single protein format |
| CHEMBL3358223 |  |
IC50 | = | 400.0 | nM | 145.16 | O=Cc1ccc2[nH]ccc2c1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL3358193 |  |
IC50 | = | 400.0 | nM | 163.2 | O=Cc1cc2ccncc2s1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL3358194 |  |
IC50 | = | 400.0 | nM | 197.69 | NCc1csc2ccc(Cl)cc12 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL3358215 |  |
IC50 | = | 400.0 | nM | 146.14 | O=Cc1ccc2occc2c1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL3358204 |  |
IC50 | = | 500.0 | nM | 241.11 | O=Cc1csc2ccc(Br)cc12 | Homo sapiens | CHEMBL3390303 | single protein format |
| CHEMBL3358195 |  |
IC50 | = | 500.0 | nM | 177.27 | CNCc1cc2ccccc2s1 | Homo sapiens | CHEMBL3390302 | single protein format |
| CHEMBL360541 |  |
IC50 | = | 514.0 | nM | 132.17 | NCC#Cc1cccnc1 | Homo sapiens | CHEMBL3705713 | single protein format |