P11474 | ERR1_HUMAN | Steroid hormone receptor ERR1 (ESRRA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 226~395 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 78~146 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL402491 |  |
IC50 | = | 3.3 | nM | 299.71 | Oc1ccc2c(c1)OCc1c-2nc2ccc(O)cc2c1Cl | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL250097 |  |
IC50 | = | 3.6 | nM | 344.16 | Oc1ccc2c(c1)OCc1c-2nc2ccc(O)cc2c1Br | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL135 |  |
IC50 | = | 3.6 | nM | 272.39 | C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL198411 |  |
IC50 | = | 4.3 | nM | 316.15 | Oc1ccc(-c2cc(Br)c3cc(O)ccc3n2)cc1 | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL4533857 |  |
IC50 | = | 4.33 | nM | 444.33 | COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F | Homo sapiens | CHEMBL4305574 | single protein format |
| CHEMBL4578651 |  |
IC50 | = | 4.33 | nM | 502.41 | COCCNC(=O)/C(C#N)=C/c1ccc(OCc2ccc(C(F)(F)F)cc2C(F)(F)F)c(OC)c1 | Homo sapiens | CHEMBL4305574 | single protein format |
| CHEMBL372783 |  |
IC50 | = | 4.6 | nM | 271.7 | Oc1ccc(-c2cc(Cl)c3cc(O)ccc3n2)cc1 | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL4440692 |  |
IC50 | = | 4.67 | nM | 560.45 | COc1cc(/C=C(\C#N)C(=O)NCCOCCC(=O)O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F | Homo sapiens | CHEMBL4305574 | single protein format |
| CHEMBL4170306 |  |
IC50 | = | 5.0 | nM | 534.99 | CN1CCC[C@H]1CN1C(=O)S/C(=C\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4514580 |  |
IC50 | = | 5.67 | nM | 445.32 | COc1cc(/C=C(\C#N)C(=O)O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F | Homo sapiens | CHEMBL4305574 | single protein format |
| CHEMBL4444248 |  |
IC50 | = | 6.0 | nM | 544.45 | COc1cc(/C=C(\C#N)C(=O)NCCCCC(=O)O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F | Homo sapiens | CHEMBL4305574 | single protein format |
| CHEMBL402492 |  |
IC50 | = | 6.1 | nM | 290.28 | N#Cc1c2c(nc3ccc(O)cc13)-c1ccc(O)cc1OC2 | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL4169272 |  |
IC50 | = | 8.0 | nM | 546.57 | COc1ccc(Cn2ncc3cc(/C=C4\SC(=O)N(CCN5CCOCC5)C4=O)ccc32)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4161346 |  |
IC50 | = | 8.0 | nM | 559.57 | COc1ccc(Cn2ncc3cc(/C=C4\SC(=O)N(C5CCC(C(=O)O)CC5)C4=O)ccc32)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4166492 |  |
IC50 | = | 8.0 | nM | 572.97 | CC(=O)NS(=O)(=O)CN1C(=O)S/C(=C\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4163909 |  |
IC50 | = | 9.0 | nM | 491.45 | COc1ccc(Cn2ncc3cc(/C=C4\SC(=O)N(CC(=O)O)C4=O)ccc32)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4159613 |  |
IC50 | = | 9.0 | nM | 495.87 | O=C(O)CN1C(=O)S/C(=C\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C1=O | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL44 |  |
IC50 | = | 10.0 | nM | 270.24 | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL886438 | single protein format |
| CHEMBL4166832 |  |
IC50 | = | 12.0 | nM | 563.99 | O=C(O)C1CCC(N2C(=O)S/C(=C\c3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)CC1 | Homo sapiens | CHEMBL4131392 | single protein format |
| CHEMBL4165363 |  |
IC50 | = | 13.0 | nM | 519.9 | O=C1S/C(=C\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)C(=O)N1Cc1nnn[nH]1 | Homo sapiens | CHEMBL4131392 | single protein format |