P11388 | TOP2A_HUMAN | DNA topoisomerase 2-alpha (TOP2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00204 | DNA_gyraseB - DNA gyrase B | 266~426 | |
| PF00521 | DNA_topoisoIV - DNA gyrase/topoisomerase IV, subunit A | 713~1171 | |
| PF01751 | Toprim - Toprim domain | 456~558 | |
| PF02518 | HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 80~176 | |
| PF08070 | DTHCT - DTHCT (NUC029) region | 1435~1522 | |
| PF16898 | TOPRIM_C - C-terminal associated domain of TOPRIM | 573~711 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // DNA_topoisoIV_1st ]
[ Domain: "alpha-helical domain in type II DNA topoisomerase" // DNA_topoisoIV_3rd ]
[ Domain: "Ribosomal protein S5 domain 2-like" // DNA_gyraseB ]
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c_1 ]
[ Domain: "SSHS domain in type II DNA topoisomerase" // TOPRIM_C ]
[ Domain: "a+b domain in type II DNA topoisomerase" // DNA_topoisoIV_2nd_1 ]
[ Domain: "Toprim domain" // DNA_gyraseB_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL440125 |  |
IC50 | = | 0.21 | nM | 364.35 | COc1ccc(-c2c3c(cc4cc5c(cc24)OCO5)C(=O)OC3)cc1OC | Homo sapiens | CHEMBL5391401 | single protein format |
| CHEMBL1117 |  |
IC50 | = | 2.6 | nM | 497.5 | CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O | Homo sapiens | CHEMBL5391401 | single protein format |
| CHEMBL417 |  |
IC50 | = | 3.0 | nM | 543.53 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 | Homo sapiens | CHEMBL5391401 | single protein format |
| CHEMBL178 |  |
IC50 | = | 10.0 | nM | 527.53 | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 | Homo sapiens | CHEMBL5391401 | single protein format |
| CHEMBL346068 |  |
IC50 | = | 60.0 | nM | 481.48 | N[C@@H]1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2Oc2c-4ccc3c2ccc2ccccc23)C1 | Homo sapiens | CHEMBL1050089 | single protein format |
| CHEMBL2296491 |  |
IC50 | = | 76.0 | nM | 377.47 | CCC(=O)NCCC1=C(SC)C(=O)c2nccc3c2c1nc1ccccc13 | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL2296492 |  |
IC50 | = | 125.0 | nM | 373.46 | COc1cc(CCNC(=O)C=C(C)C)c2c3c(ccnc13)-c1ccccc1N2 | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL2296490 |  |
IC50 | = | 132.0 | nM | 347.37 | COC1=C(CCNC(C)=O)c2nc3ccccc3c3ccnc(c23)C1=O | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL4463643 |  |
IC50 | = | 200.0 | nM | 318.33 | CC(=O)Nc1ccc2c(-c3cc4ccccc4o3)ccnc2c1O | Homo sapiens | CHEMBL4324042 | single protein format |
| CHEMBL164 |  |
IC50 | = | 390.0 | nM | 318.24 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL3056567 | single protein format |
| CHEMBL2296496 |  |
IC50 | = | 592.0 | nM | 399.45 | C/C=C(\C)C(=O)C(CNCC=O)C1=CC(=O)c2nccc3c2c1nc1ccccc13 | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL2296497 |  |
IC50 | = | 592.0 | nM | 399.45 | CC(C)=CC(=O)C(CNCC=O)C1=CC(=O)c2nccc3c2c1nc1ccccc13 | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL4527023 |  |
IC50 | = | 600.0 | nM | 411.43 | O=C(CCN1CCOCC1)Nc1ccc2c(-c3cc(F)ccc3O)ccnc2c1O | Homo sapiens | CHEMBL4324042 | single protein format |
| CHEMBL2296494 |  |
IC50 | = | 639.0 | nM | 417.47 | CC(C)(O)CC(=O)C(CNCC=O)C1=CC(=O)c2nccc3c2c1nc1ccccc13 | Homo sapiens | CHEMBL3074820 | single protein format |
| CHEMBL5408150 |  |
IC50 | = | 670.0 | nM | 577.3 | Cc1[nH]c(C(=O)Nc2ccc(C(N)=O)cc2OCc2ccc(C(=O)NCCN)cc2)c(Cl)c1Cl.Cl.Cl | Homo sapiens | CHEMBL5347792 | single protein format |
| CHEMBL1305588 |  |
IC50 | = | 680.0 | nM | 267.34 | c1ccc2c(c1)nc(NC1CCCCC1)c1nncn12 | Homo sapiens | CHEMBL4271923 | single protein format |
| CHEMBL4552030 |  |
IC50 | = | 700.0 | nM | 346.31 | CC(=O)Nc1ccc2c(-c3ccc(C(F)(F)F)cc3)ccnc2c1O | Homo sapiens | CHEMBL4324042 | single protein format |
| CHEMBL155344 |  |
IC50 | = | 700.0 | nM | 481.48 | N[C@H]1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2Oc2c-4ccc3c2ccc2ccccc23)C1 | Homo sapiens | CHEMBL1050089 | single protein format |
| CHEMBL5414329 |  |
IC50 | = | 730.0 | nM | 490.61 | CCc1nc2nc(Nc3ccc4nc(OCCN5CCOCC5)ccc4c3)nc(NC(C)(C)C)c2[nH]1 | Homo sapiens | CHEMBL5347792 | single protein format |
| CHEMBL4288104 |  |
IC50 | = | 850.0 | nM | 405.44 | COc1cccc(NC(=O)CSc2nnc3c4nncn4c4ccccc4n23)c1 | Homo sapiens | CHEMBL4271923 | single protein format |