P11274 | BCR_HUMAN | Breakpoint cluster region protein (BCR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 913~1007 | |
| PF00620 | RhoGAP - RhoGAP domain | 1068~1215 | |
| PF00621 | RhoGEF - RhoGEF domain | 503~689 | |
| PF09036 | Bcr-Abl_Oligo - Bcr-Abl oncoprotein oligomerisation domain | 3~75 | |
| PF19057 | PH_19 - PH domain | 703~781 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // PH_10 ]
[ Domain: "DBL homology domain (DH-domain)" // RhoGEF ]
[ Domain: "Bcr-Abl oncoprotein oligomerization domain" // Bcr-Abl_Oligo ]
[ Domain: "Bcr-Abl oncoprotein oligomerization domain" // Bcr-Abl_Oligo ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL434335 |  |
IC50 | = | 573.0 | nM | 439.52 | Cc1ccc(NC(=O)Nc2cccc(N(C)C)c2)cc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL832728 | single protein format |
| CHEMBL184742 |  |
IC50 | = | 720.0 | nM | 465.56 | Cc1ccc(NC(=O)Nc2cccc(N3CCCC3)c2)cc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL832728 | single protein format |