P11217 | PYGM_HUMAN | Glycogen phosphorylase, muscle form (PYGM)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00343 | Phosphorylase - Carbohydrate phosphorylase | 115~828 |
3D structures mapped by conservation among orthologs
[ Domain: "UDP-Glycosyltransferase/glycogen phosphorylase" // Phosphorylase_C ]
[ Domain: "UDP-Glycosyltransferase/glycogen phosphorylase" // Phosphorylase_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL134802 |  |
IC50 | = | 3.0 | nM | 473.4 | O=C(Nc1cc2ccccc2cc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL115651 |  |
IC50 | = | 6.0 | nM | 504.37 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL113736 |  |
IC50 | = | 8.28 | nM | 420.89 | CCN1C(C)=C(C(=O)NCC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C1C(=O)O | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL133911 |  |
IC50 | = | 9.0 | nM | 441.33 | O=C(Nc1c(F)cccc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL423509 |  |
IC50 | = | 10.0 | nM | 514.92 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL326950 |  |
IC50 | = | 10.61 | nM | 454.91 | CCN1C(C)=C(C(=O)NCc2ccccc2)C(c2ccccc2Cl)C(C(=O)O)=C1C(=O)O | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL115341 |  |
IC50 | = | 11.0 | nM | 529.97 | COc1ccc(CN2C(C)=C(C(=O)OC(C)C)C(c3ccccc3Cl)C(C(=O)O)=C2C(=O)O)cc1OC | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL133832 |  |
IC50 | = | 12.0 | nM | 462.85 | O=C(Nc1cc2ccccc2cc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc(Cl)ccn1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL440528 |  |
IC50 | = | 12.0 | nM | 458.43 | COc1ccnc(C(=O)Nc2cc3ccccc3cc2Oc2ccc(C(=O)O)c(C(=O)O)c2)c1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL114226 |  |
IC50 | = | 12.9 | nM | 406.87 | CCN1C(C)=C(C(=O)NC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C1C(=O)O | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL139472 |  |
IC50 | = | 14.0 | nM | 339.78 | O=C(N[C@@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | Homo sapiens | CHEMBL680571 | tissue-based format |
| CHEMBL114846 |  |
IC50 | = | 19.9 | nM | 392.84 | CCNC(=O)C1=C(C)N(CC)C(C(=O)O)=C(C(=O)O)C1c1ccccc1Cl | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL132191 |  |
IC50 | = | 25.0 | nM | 423.34 | O=C(Nc1ccccc1Oc1ccc(C(=O)O)c(C(=O)O)c1)c1cc([N+](=O)[O-])ccn1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL114731 |  |
IC50 | = | 26.0 | nM | 469.92 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1ccccc1 | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL133274 |  |
IC50 | = | 29.0 | nM | 456.45 | CCc1ccnc(C(=O)Nc2cc3ccccc3cc2Oc2ccc(C(=O)O)c(C(=O)O)c2)c1 | Homo sapiens | CHEMBL680562 | tissue-based format |
| CHEMBL113762 |  |
IC50 | = | 29.0 | nM | 504.37 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL337332 |  |
IC50 | = | 32.0 | nM | 353.81 | CN1C(=O)C(NC(=O)c2cc3cc(Cl)ccc3[nH]2)Cc2ccccc21 | Homo sapiens | CHEMBL680571 | tissue-based format |
| CHEMBL115441 |  |
IC50 | = | 37.0 | nM | 538.81 | CC1=C(C(=O)OC(C)C)C(c2ccccc2Cl)C(C(=O)O)=C(C(=O)O)N1Cc1cc(Cl)cc(Cl)c1 | Homo sapiens | CHEMBL873438 | tissue-based format |
| CHEMBL139461 |  |
IC50 | = | 38.0 | nM | 339.78 | O=C(NC1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | Homo sapiens | CHEMBL680571 | tissue-based format |
| CHEMBL134854 |  |
IC50 | = | 39.0 | nM | 339.78 | O=C(N[C@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 | Homo sapiens | CHEMBL680571 | tissue-based format |