P11169 | GTR3_HUMAN | Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00083 | Sugar_tr - Sugar (and other) transporter | 14~465 |
3D structures mapped by conservation among orthologs
[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1 ]
[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3781913 |  |
IC50 | = | 8.0 | nM | 400.49 | COc1ccccc1N1CCCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780239 |  |
IC50 | = | 10.0 | nM | 404.45 | COc1ccc(F)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL4645691 |  |
IC50 | = | 12.0 | nM | 498.59 | CCC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL4647311 |  |
IC50 | = | 26.0 | nM | 498.59 | CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL4634839 |  |
IC50 | = | 33.0 | nM | 512.61 | CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL3781331 |  |
IC50 | = | 37.0 | nM | 429.48 | COc1ccc(C(N)=O)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3781548 |  |
IC50 | = | 40.0 | nM | 404.45 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2F)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780972 |  |
IC50 | = | 40.0 | nM | 404.45 | COc1cc(F)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3781151 |  |
IC50 | = | 46.0 | nM | 404.45 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL4634011 |  |
IC50 | = | 47.0 | nM | 496.57 | O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCCC1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL3780144 |  |
IC50 | = | 50.0 | nM | 411.47 | COc1ccc(C#N)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL4633651 |  |
IC50 | = | 58.0 | nM | 497.6 | CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL3781149 |  |
IC50 | = | 60.0 | nM | 372.43 | Oc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780372 |  |
IC50 | = | 60.0 | nM | 387.45 | COc1ccncc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780785 |  |
IC50 | = | 64.0 | nM | 386.46 | COc1ccccc1N1CCN(c2ncnc3c2ncn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL4638234 |  |
IC50 | = | 68.0 | nM | 482.54 | O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCC1 | Homo sapiens | CHEMBL4605537 | cell-based format |
| CHEMBL3780717 |  |
IC50 | = | 69.0 | nM | 381.44 | N#Cc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3781835 |  |
IC50 | = | 70.0 | nM | 387.45 | COc1cccnc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780460 |  |
IC50 | = | 90.0 | nM | 422.44 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)cc(F)c2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |
| CHEMBL3780043 |  |
IC50 | = | 96.0 | nM | 400.49 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C)c2)CC1 | Homo sapiens | CHEMBL3782732 | cell-based format |