P11166 | GTR1_HUMAN | Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00083 | Sugar_tr - Sugar (and other) transporter | 19~466 |
3D structures mapped by conservation among orthologs
[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1 ]
[ Domain: "Major facilitator superfamily (MFS) general substrate transporter" // MFS_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3780239 |  |
IC50 | = | 1.0 | nM | 404.45 | COc1ccc(F)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL4448899 |  |
IC50 | = | 2.0 | nM | 496.42 | Cc1c(NC(=O)c2cc(C(N)=O)nc3cc(F)ccc23)c(C(F)(F)F)nn1Cc1ccc(C#N)cc1 | Homo sapiens | CHEMBL4357107 | cell-based format |
| CHEMBL3781913 |  |
IC50 | = | 4.0 | nM | 400.49 | COc1ccccc1N1CCCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL4092369 |  |
IC50 | = | 4.9 | nM | 577.72 | C/C=C(\C)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](C)/C=C(C)/C=C/C/C(C)=C/Cc1nc(OC)c(OC)c(O)c1C | Homo sapiens | CHEMBL3992745 | cell-based format |
| CHEMBL3781331 |  |
IC50 | = | 5.0 | nM | 429.48 | COc1ccc(C(N)=O)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781149 |  |
IC50 | = | 7.0 | nM | 372.43 | Oc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781548 |  |
IC50 | = | 7.0 | nM | 404.45 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2F)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780460 |  |
IC50 | = | 8.0 | nM | 422.44 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)cc(F)c2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780372 |  |
IC50 | = | 9.0 | nM | 387.45 | COc1ccncc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781347 |  |
IC50 | = | 10.0 | nM | 400.49 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2C)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780972 |  |
IC50 | = | 10.0 | nM | 404.45 | COc1cc(F)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781308 |  |
IC50 | = | 14.0 | nM | 400.49 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1C | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781194 |  |
IC50 | = | 17.0 | nM | 411.47 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(C#N)cc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781151 |  |
IC50 | = | 17.0 | nM | 404.45 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780144 |  |
IC50 | = | 20.0 | nM | 411.47 | COc1ccc(C#N)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781157 |  |
IC50 | = | 25.0 | nM | 386.46 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780785 |  |
IC50 | = | 27.0 | nM | 386.46 | COc1ccccc1N1CCN(c2ncnc3c2ncn3-c2ccccc2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780470 |  |
IC50 | = | 30.0 | nM | 434.48 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)ccc2OC)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3780765 |  |
IC50 | = | 33.0 | nM | 411.47 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C#N)c2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |
| CHEMBL3781741 |  |
IC50 | = | 35.0 | nM | 404.45 | COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(F)c2)CC1 | Homo sapiens | CHEMBL3782730 | cell-based format |