P11150 | LIPC_HUMAN | Hepatic triacylglycerol lipase (LIPC)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00151 | Lipase - Lipase | 21~349 | |
| PF01477 | PLAT - PLAT/LH2 domain | 354~471 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3677564 |  |
IC50 | = | 0.5 | nM | 485.59 | COCCS(=O)(=O)C(C(=O)NCc1cc(C)no1)c1nc2ccc(-c3ccccc3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677538 |  |
IC50 | = | 0.8 | nM | 488.01 | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(-c3cccc(Cl)c3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677562 |  |
IC50 | = | 0.8 | nM | 513.64 | COCCS(=O)(=O)C(C(=O)NCc1cc(C(C)C)no1)c1nc2ccc(-c3ccccc3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677630 |  |
IC50 | = | 1.0 | nM | 471.56 | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(-c3ccccc3F)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3672652 |  |
IC50 | = | 1.0 | nM | 522.67 | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(-c3cccc(N4CCCC4)c3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677580 |  |
IC50 | = | 1.4 | nM | 469.59 | CC(C)c1cc(CNC(=O)C(c2nc3ccc(-c4ccccc4)cc3s2)S(C)(=O)=O)on1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677632 |  |
IC50 | = | 1.5 | nM | 553.58 | NS(=O)(=O)CCNC(=O)C(c1nc2ccc(-c3ccccc3F)cc2s1)S(=O)(=O)CCC(F)(F)F | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677540 |  |
IC50 | = | 1.9 | nM | 545.66 | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(-c3cccc(Oc4ccccc4)c3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3672654 |  |
IC50 | = | 1.9 | nM | 570.67 | COCCOC(=O)Nc1ccc(-c2ccc3nc(C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O)sc3c2)cc1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL4463265 |  |
IC50 | = | 2.0 | nM | 415.46 | NS(=O)(=O)NCc1nnc(C(=O)c2nc3ccc(-c4ccccc4)cc3s2)o1 | Homo sapiens | CHEMBL4325753 | cell-based format |
| CHEMBL3677434 |  |
IC50 | = | 2.2 | nM | 484.58 | COc1cc(-c2ccc3sc(C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O)nc3c2)ccn1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677571 |  |
IC50 | = | 2.4 | nM | 582.1 | NS(=O)(=O)CCNC(=O)C(c1nc2ccc(-c3cccc(Cl)c3)cc2s1)S(=O)(=O)Cc1ccc(F)cc1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3672653 |  |
IC50 | = | 2.6 | nM | 497.62 | COCc1ccc(-c2ccc3nc(C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O)sc3c2)cc1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677433 |  |
IC50 | = | 2.6 | nM | 484.58 | COc1ccc(-c2ccc3sc(C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O)nc3c2)cn1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677610 |  |
IC50 | = | 2.6 | nM | 535.59 | NS(=O)(=O)CCNC(=O)C(c1nc2ccc(-c3ccccc3)cc2s1)S(=O)(=O)CCC(F)(F)F | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677607 |  |
IC50 | = | 2.8 | nM | 558.71 | Cc1nnc(CNC(=O)C(c2nc3ccc(-c4ccc(C(=O)OC(C)(C)C)cc4)cc3s2)S(C)(=O)=O)s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677550 |  |
IC50 | = | 2.8 | nM | 542.66 | CC(C)(C)OC(=O)n1ccc(-c2ccc3nc(C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O)sc3c2)c1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677537 |  |
IC50 | = | 2.8 | nM | 488.01 | CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(-c3ccc(Cl)cc3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3677608 |  |
IC50 | = | 2.9 | nM | 599.73 | CC(C)S(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2c(F)cc(-c3cccc(C(=O)OC(C)(C)C)c3)cc2s1 | Homo sapiens | CHEMBL3707962 | single protein format |
| CHEMBL3890635 |  |
IC50 | = | 3.0 | nM | 429.48 | CN(Cc1nnc(C(=O)c2nc3ccc(-c4ccccc4)cc3s2)o1)S(N)(=O)=O | Homo sapiens | CHEMBL4325753 | cell-based format |