3D structures mapped by conservation among orthologs

[ Domain: "Heat shock protein 70kD (HSP70), peptide-binding domain" // HSP70_2nd ]

 PyMOL session

[ Domain: "Heat shock protein 70kD (HSP70), C-terminal subdomain" // HSP70_3rd ]

 PyMOL session

[ Domain: "Ribonuclease H-like" // HSP70_1st ]

 PyMOL session

[ Domain: "Ribonuclease H-like" // MreB_Mbl_C ]

 PyMOL session

[ Domain: "RING/U-box" // ZZ ]

 PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

 IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL5418499		IC50	<	500.0	nM	293.35	CC(C)[C@H](NC(=O)c1ccco1)C(=O)Nc1nccs1	Homo sapiens	CHEMBL5321341	single protein format
CHEMBL5415571		IC50	<	500.0	nM	310.4	CC(C)[C@H](NC(=O)c1nccs1)C(=O)Nc1nccs1	Homo sapiens	CHEMBL5321341	single protein format
CHEMBL5410116		IC50	<	500.0	nM	384.51	CC[C@@H](C)[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)Nc1nc(C)c(C)s1	Homo sapiens	CHEMBL5321341	single protein format
CHEMBL5414287		IC50	=	590.0	nM	342.42	CC(C)[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)Nc1nccs1	Homo sapiens	CHEMBL5321341	single protein format
CHEMBL5419391		IC50	=	700.0	nM	323.44	CCCC[C@H](NC(=O)c1cccs1)C(=O)Nc1nccs1	Homo sapiens	CHEMBL5321341	single protein format
CHEMBL470334		IC50	=	800.0	nM	556.41	N#Cc1ccc(COC[C@H]2O[C@@H](n3c(NCc4ccc(Cl)c(Cl)c4)nc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1	Homo sapiens	CHEMBL4388992	cell-based format