P10828 | THB_HUMAN | Thyroid hormone receptor beta (THRB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 269~435 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 106~175 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL289343 |  |
IC50 | = | 0.025 | nM | 458.15 | CC(C)c1cc(Oc2c(Br)cc(CCC(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL814601 | single protein format |
| CHEMBL203777 |  |
IC50 | = | 0.06 | nM | 380.23 | CC(C)c1cc(Oc2c(Cl)cc3[nH]c(C(=O)O)cc3c2Cl)ccc1O | Homo sapiens | CHEMBL866542 | single protein format |
| CHEMBL4114879 |  |
IC50 | = | 0.09 | nM | 505.97 | COc1cc(C(=O)N2CC(C)(CCO)OC[C@H]2C)cc2nc(N[C@H](CF)c3cccc(Cl)c3)oc12 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL39174 |  |
IC50 | = | 0.095 | nM | 444.12 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL814601 | single protein format |
| CHEMBL41314 |  |
IC50 | = | 0.11 | nM | 567.16 | CC(C)c1cc(Oc2c(I)cc(C[C@@H](N)C(=O)O)cc2I)ccc1O | Homo sapiens | CHEMBL814601 | single protein format |
| CHEMBL418432 |  |
IC50 | = | 0.15 | nM | 369.24 | CC(C)c1cc(Oc2c(Cl)cc(CCC(=O)O)cc2Cl)ccc1O | Homo sapiens | CHEMBL814601 | single protein format |
| CHEMBL4761137 |  |
IC50 | = | 0.27 | nM | 473.96 | COc1cc(C(=O)N2CC(C)C(O)CC2CCO)cc2nc(NCc3cccc(Cl)c3)oc12 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL236289 |  |
IC50 | = | 0.27 | nM | 543.25 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@H](C(=O)O)C(C)C)cc2Br)ccc1O | Homo sapiens | CHEMBL896601 | cell-based format |
| CHEMBL425939 |  |
IC50 | = | 0.28 | nM | 469.13 | CC(C)c1cc(Oc2c(Br)cc3[nH]c(C(=O)O)cc3c2Br)ccc1O | Homo sapiens | CHEMBL866542 | single protein format |
| CHEMBL194242 |  |
IC50 | = | 0.3 | nM | 469.12 | O=C(O)CC(=O)Nc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL882591 | single protein format |
| CHEMBL4114862 |  |
IC50 | = | 0.3 | nM | 517.99 | COc1cc(C(=O)N2CC(C)OCC2C2CC(O)C2)cc2nc(N[C@H](CF)c3cccc(Cl)c3)oc12 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL198367 |  |
IC50 | = | 0.3 | nM | 455.09 | O=C(O)C(=O)Nc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL882591 | single protein format |
| CHEMBL196642 |  |
IC50 | = | 0.3 | nM | 446.33 | COc1ccc2c(-c3c(Cl)cc(NC(=O)CC(=O)O)cc3Cl)cccc2c1C(C)C | Homo sapiens | CHEMBL882591 | single protein format |
| CHEMBL4749829 |  |
IC50 | = | 0.4 | nM | 502.01 | CC[C@@H]1CO[C@@](C)(CCO)CN1C(=O)c1cc(OC)c2oc(N[C@H](C)c3cccc(Cl)c3)nc2c1 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL4754786 |  |
IC50 | = | 0.5 | nM | 487.98 | COc1cc(C(=O)N2CC(C)(CCO)OC[C@H]2C)cc2nc(N[C@H](C)c3cccc(Cl)c3)oc12 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL236291 |  |
IC50 | = | 0.6 | nM | 577.27 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@@H](C(=O)O)c3ccccc3)cc2Br)ccc1O | Homo sapiens | CHEMBL896601 | cell-based format |
| CHEMBL4763593 |  |
IC50 | = | 0.7 | nM | 491.95 | COc1cc(C(=O)N2C[C@H](C)OC[C@@H]2CCO)cc2nc(N[C@H](CF)c3cccc(Cl)c3)oc12 | Homo sapiens | CHEMBL4672669 | single protein format |
| CHEMBL391512 |  |
IC50 | = | 0.71 | nM | 543.25 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@@H](C(=O)O)C(C)C)cc2Br)ccc1O | Homo sapiens | CHEMBL896601 | cell-based format |
| CHEMBL236290 |  |
IC50 | = | 0.78 | nM | 577.27 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@H](C(=O)O)c3ccccc3)cc2Br)ccc1O | Homo sapiens | CHEMBL896601 | cell-based format |
| CHEMBL41036 |  |
IC50 | = | 1.1 | nM | 355.22 | CC(C)c1cc(Oc2c(Cl)cc(CC(=O)O)cc2Cl)ccc1O | Homo sapiens | CHEMBL814601 | single protein format |