P10827 | THA_HUMAN | Thyroid hormone receptor alpha (THRA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 215~376 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 52~121 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL289343 |  |
IC50 | = | 0.1 | nM | 458.15 | CC(C)c1cc(Oc2c(Br)cc(CCC(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL41314 |  |
IC50 | = | 0.14 | nM | 567.16 | CC(C)c1cc(Oc2c(I)cc(C[C@@H](N)C(=O)O)cc2I)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL418432 |  |
IC50 | = | 0.76 | nM | 369.24 | CC(C)c1cc(Oc2c(Cl)cc(CCC(=O)O)cc2Cl)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL39174 |  |
IC50 | = | 1.4 | nM | 444.12 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL203777 |  |
IC50 | = | 1.4 | nM | 380.23 | CC(C)c1cc(Oc2c(Cl)cc3[nH]c(C(=O)O)cc3c2Cl)ccc1O | Homo sapiens | CHEMBL866541 | single protein format |
| CHEMBL425939 |  |
IC50 | = | 2.5 | nM | 469.13 | CC(C)c1cc(Oc2c(Br)cc3[nH]c(C(=O)O)cc3c2Br)ccc1O | Homo sapiens | CHEMBL866541 | single protein format |
| CHEMBL194242 |  |
IC50 | = | 4.3 | nM | 469.12 | O=C(O)CC(=O)Nc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL880611 | single protein format |
| CHEMBL236289 |  |
IC50 | = | 4.3 | nM | 543.25 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@H](C(=O)O)C(C)C)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL198367 |  |
IC50 | = | 5.4 | nM | 455.09 | O=C(O)C(=O)Nc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL880611 | single protein format |
| CHEMBL236291 |  |
IC50 | = | 5.5 | nM | 577.27 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@@H](C(=O)O)c3ccccc3)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL236290 |  |
IC50 | = | 7.5 | nM | 577.27 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@H](C(=O)O)c3ccccc3)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL289965 |  |
IC50 | = | 9.7 | nM | 430.09 | CC(C)c1cc(Oc2c(Br)cc(C(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL391512 |  |
IC50 | = | 9.8 | nM | 543.25 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@@H](C(=O)O)C(C)C)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL391367 |  |
IC50 | = | 10.0 | nM | 515.2 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)N[C@@H](C)C(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL198875 |  |
IC50 | = | 13.0 | nM | 455.13 | O=C(O)CCNc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL880611 | single protein format |
| CHEMBL196642 |  |
IC50 | = | 14.0 | nM | 446.33 | COc1ccc2c(-c3c(Cl)cc(NC(=O)CC(=O)O)cc3Cl)cccc2c1C(C)C | Homo sapiens | CHEMBL880611 | single protein format |
| CHEMBL193864 |  |
IC50 | = | 19.0 | nM | 441.11 | O=C(O)CNc1cc(Cl)c(-c2cccc3c(Br)c(O)ccc23)c(Cl)c1 | Homo sapiens | CHEMBL880611 | single protein format |
| CHEMBL41036 |  |
IC50 | = | 25.0 | nM | 355.22 | CC(C)c1cc(Oc2c(Cl)cc(CC(=O)O)cc2Cl)ccc1O | Homo sapiens | CHEMBL873891 | single protein format |
| CHEMBL236080 |  |
IC50 | = | 26.0 | nM | 501.17 | CC(C)c1cc(Oc2c(Br)cc(CC(=O)NCC(=O)O)cc2Br)ccc1O | Homo sapiens | CHEMBL896600 | cell-based format |
| CHEMBL217221 |  |
IC50 | = | 36.0 | nM | 561.27 | CC(C)c1cc(Oc2c(Br)cc(CCC(=O)O)cc2Br)cc(/C=C/c2ccncc2)c1O | Homo sapiens | CHEMBL856619 | single protein format |