P10826 | RARB_HUMAN | Retinoic acid receptor beta (RARB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 227~399 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 87~155 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL38 |  |
IC50 | = | 0.94 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL879257 | single protein format |
| CHEMBL131925 |  |
IC50 | = | 2.5 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)co3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL131850 |  |
IC50 | = | 4.5 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)cs3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL275311 |  |
IC50 | = | 5.0 | nM | 348.49 | C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799696 | single protein format |
| CHEMBL705 |  |
IC50 | = | 7.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL799696 | single protein format |
| CHEMBL336311 |  |
IC50 | = | 21.0 | nM | 393.51 | CC1(C)CCC(C)(C)c2nc(-c3csc(-c4ccc(C(=O)O)cc4)n3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL131810 |  |
IC50 | = | 36.0 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)s3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL132033 |  |
IC50 | = | 39.0 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)o3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL550796 |  |
IC50 | = | 40.0 | nM | 380.48 | CC(=C\c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C)/C=C(\C)C(=O)O | Homo sapiens | CHEMBL1063214 | single protein format |
| CHEMBL284937 |  |
IC50 | = | 75.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799696 | single protein format |
| CHEMBL134375 |  |
IC50 | = | 100.0 | nM | 373.5 | CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)ccc21 | Homo sapiens | CHEMBL798908 | single protein format |
| CHEMBL432592 |  |
IC50 | = | 140.0 | nM | 353.42 | CC1(C)CCC(C)(C)c2nc(C(=O)Nc3ccc(C(=O)O)cc3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL424636 |  |
IC50 | = | 150.0 | nM | 390.57 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C(C)C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799696 | single protein format |
| CHEMBL133725 |  |
IC50 | = | 230.0 | nM | 375.47 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL337855 |  |
IC50 | = | 290.0 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)[nH]n3)cnc21 | Homo sapiens | CHEMBL798909 | single protein format |
| CHEMBL275311 | |
Ki | = | 0.5 | nM | 348.49 | C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL818520 | single protein format |
| CHEMBL38 | |
Ki | = | 0.5 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL820187 | single protein format |
| CHEMBL705 | |
Ki | = | 0.7 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL818520 | single protein format |
| CHEMBL36768 |  |
Ki | = | 3.0 | nM | 358.48 | CC1(C)CCC(C)(C)c2cc3cc(-c4ccc(C(=O)O)cc4)ccc3cc21 | Homo sapiens | CHEMBL798917 | single protein format |
| CHEMBL74331 |  |
Ki | = | 11.0 | nM | 314.47 | CC(/C=C/C1CC1/C=C/C1=CC(C)(C)CCC1(C)C)=C\C(=O)O | Homo sapiens | CHEMBL820187 | single protein format |