P10721 | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (KIT)

Pfam Domain Table

AccessionDomainRangeColor
PF00047ig - Immunoglobulin domain220~302
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase590~922

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_1 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3975634 IC50 = 0.18 nM 452.51 CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 Homo sapiens CHEMBL3707563 single protein format
CHEMBL2079588 IC50 = 1.0 nM 409.83 CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1 Homo sapiens CHEMBL4839226 single protein format
CHEMBL3628797 IC50 = 1.0 nM 434.3 O=C(Nc1ccc(Nc2ncnc3ccccc23)cc1)Nc1cccc(Br)c1 Homo sapiens CHEMBL3631063 single protein format
CHEMBL494821 IC50 = 1.0 nM 348.45 Cc1ccn(CCC2CCCC2)c(=O)c1-c1ccc2nc(N)ncc2c1 Homo sapiens CHEMBL955806 single protein format
CHEMBL1276980 IC50 = 1.0 nM 454.5 Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2 Homo sapiens CHEMBL1285787 single protein format
CHEMBL1276891 IC50 = 1.0 nM 424.48 Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2 Homo sapiens CHEMBL1285787 single protein format
CHEMBL248256 IC50 = 1.0 nM 440.41 CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 Homo sapiens CHEMBL922915 single protein format
CHEMBL488984 IC50 = 1.0 nM 448.79 Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 Homo sapiens CHEMBL990799 single protein format
CHEMBL1278234 IC50 = 1.0 nM 382.44 Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN(C)C)CC2 Homo sapiens CHEMBL1285787 single protein format
CHEMBL3628798 IC50 = 1.0 nM 440.33 O=C(Nc1ccc(Nc2ncnc3sccc23)cc1)Nc1cccc(Br)c1 Homo sapiens CHEMBL3631063 single protein format
CHEMBL490823 IC50 = 1.0 nM 489.84 CC(=O)Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(C(F)(F)F)c4)noc23)cn1 Homo sapiens CHEMBL990799 single protein format
CHEMBL4847875 IC50 = 1.1 nM 482.47 CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 Homo sapiens CHEMBL4845025 single protein format
CHEMBL2206278 IC50 = 1.2 nM 562.72 CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C Homo sapiens CHEMBL2213409 cell-based format
CHEMBL4074755 IC50 = 1.4 nM 351.45 CCCCCCNC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 Homo sapiens CHEMBL4012622 single protein format
CHEMBL2430262 IC50 = 1.4 nM 369.4 Cc1[nH]c2c(c1C(=O)NCCO)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 Homo sapiens CHEMBL2434540 single protein format
CHEMBL1173149 IC50 = 1.5 nM 374.4 COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)cc1 Homo sapiens CHEMBL1176710 single protein format
CHEMBL4860486 IC50 = 1.5 nM 442.48 Cc1nc(-c2ccc(CNc3cc(-c4cnc5cc(OCCO)ccn45)ncn3)cc2)co1 Homo sapiens CHEMBL4825222 single protein format
CHEMBL4101428 IC50 = 1.7 nM 385.47 Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCCc4ccccc4)cc3)c12 Homo sapiens CHEMBL4012622 single protein format
CHEMBL2336040 IC50 = 1.9 nM 382.42 COc1cccc(NC(=O)c2ccc(C)c(C#Cc3cnc4ccnn4c3)c2)c1 Homo sapiens CHEMBL2342534 single protein format
CHEMBL4091975 IC50 = 1.9 nM 394.44 Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cnc5ccccc5c4)cc3)c12 Homo sapiens CHEMBL4012622 single protein format