P10636 | TAU_HUMAN | Microtubule-associated protein tau (MAPT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00418 | Tubulin-binding - Tau and MAP protein, tubulin-binding repeat | 566~591 | |
| PF00418 | Tubulin-binding - Tau and MAP protein, tubulin-binding repeat | 592~621 | |
| PF00418 | Tubulin-binding - Tau and MAP protein, tubulin-binding repeat | 623~653 | |
| PF00418 | Tubulin-binding - Tau and MAP protein, tubulin-binding repeat | 654~685 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5278104 |  |
IC50 | = | 0.4 | nM | 395.46 | CC1(C)COCCN1c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL3286988 |  |
IC50 | = | 1.0 | nM | 414.87 | COc1cc(/C=c2\sc3nc(-c4cccc(Cl)c4)cn3c2=O)cc(OC)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL2203332 |  |
IC50 | = | 1.41 | nM | 502.48 | CCCC[N+]1=C(/C=C/c2ccc(N(CC)CC)cc2)C(C)(C)c2ccccc21.[I-] | Homo sapiens | CHEMBL2212819 | assay format |
| CHEMBL5291181 |  |
IC50 | = | 1.7 | nM | 449.89 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)[C@H]2C[C@H](Cl)C2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL5284020 |  |
IC50 | = | 1.9 | nM | 449.89 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)[C@H]2C[C@@H](Cl)C2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL3286983 |  |
IC50 | = | 2.0 | nM | 419.29 | COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(Cl)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL5290966 |  |
IC50 | = | 2.0 | nM | 381.44 | C[C@H]1COCCN1c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL3286984 |  |
IC50 | = | 2.0 | nM | 463.74 | COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(Br)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL3286982 |  |
IC50 | = | 2.0 | nM | 414.87 | COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(OC)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL2181532 |  |
IC50 | = | 2.0 | nM | 422.58 | C(=C/c1cc(/C=C/c2ccc(N3CCCC3)cc2)ncn1)\c1ccc(N2CCCC2)cc1 | Homo sapiens | CHEMBL2187911 | single protein format |
| CHEMBL2181533 |  |
IC50 | = | 2.0 | nM | 422.58 | CN(C)c1ccc(/C=C/C=C/c2cc(/C=C/C=C/c3ccc(N(C)C)cc3)ncn2)cc1 | Homo sapiens | CHEMBL2187911 | single protein format |
| CHEMBL5268011 |  |
IC50 | = | 2.8 | nM | 340.38 | CC(C)(O)c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL3286989 |  |
IC50 | = | 3.0 | nM | 452.84 | COc1cc(/C=c2\sc3nc(-c4cccc(C(F)(F)F)c4)cn3c2=O)cc(Cl)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL5084771 |  |
IC50 | = | 3.1 | nM | 263.27 | Fc1cc(-c2ccc3c(c2)[nH]c2ccncc23)ccn1 | Homo sapiens | CHEMBL5055347 | tissue-based format |
| CHEMBL5082735 |  |
IC50 | = | 3.5 | nM | 263.27 | Fc1ncccc1-c1ccc2c(c1)[nH]c1ccncc12 | Homo sapiens | CHEMBL5055347 | tissue-based format |
| CHEMBL2181045 |  |
IC50 | = | 4.0 | nM | 370.5 | CN(C)c1ccc(/C=C/c2cc(/C=C/c3ccc(N(C)C)cc3)ncn2)cc1 | Homo sapiens | CHEMBL2187911 | single protein format |
| CHEMBL5088921 |  |
IC50 | = | 4.9 | nM | 264.26 | Fc1cc(-c2ccc3c(n2)[nH]c2ccncc23)ccn1 | Homo sapiens | CHEMBL5055347 | tissue-based format |
| CHEMBL3286985 |  |
IC50 | = | 5.0 | nM | 400.84 | COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(O)c1O | Homo sapiens | CHEMBL3291775 | single protein format |
| CHEMBL5282887 |  |
IC50 | = | 5.0 | nM | 401.42 | O=C(Nc1cnccc1N1CCC(F)(F)CC1)c1ccnc(NC(=O)C2CC2)c1 | Homo sapiens | CHEMBL5241009 | single protein format |
| CHEMBL3286981 |  |
IC50 | = | 5.0 | nM | 381.41 | COc1cc(/C=c2\sc3nc(-c4ccncc4)cn3c2=O)cc(OC)c1O | Homo sapiens | CHEMBL3291775 | single protein format |