P10635 | CP2D6_HUMAN | Cytochrome P450 2D6 (CYP2D6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 34~493 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3898132 |  |
IC50 | = | 5.5 | nM | 453.35 | Cn1cc(-c2nc3c(N4CCN(Cc5cccnc5)CC4)c(Br)cnc3[nH]2)cn1 | Homo sapiens | CHEMBL3889071 | single protein format |
| CHEMBL1294 |  |
IC50 | = | 8.1 | nM | 324.42 | C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12 | Homo sapiens | CHEMBL4707441 | single protein format |
| CHEMBL3923804 |  |
IC50 | = | 9.0 | nM | 324.42 | C=C[C@H]1CN2CCC1CC2[C@@H](O)c1ccnc2ccc(OC)cc12 | Homo sapiens | CHEMBL3887122 | single protein format |
| CHEMBL157138 |  |
IC50 | = | 16.0 | nM | 338.46 | CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL3942279 |  |
IC50 | < | 30.0 | nM | 467.47 | C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CO1 | Homo sapiens | CHEMBL3887162 | single protein format |
| CHEMBL3904953 |  |
IC50 | < | 30.0 | nM | 520.46 | NC1=N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)CO[C@@H](C(F)(F)F)C[C@H]2CS1 | Homo sapiens | CHEMBL3887162 | single protein format |
| CHEMBL2207501 |  |
IC50 | = | 30.0 | nM | 427.9 | Cc1nc(CN2CCN(c3c(Cl)cnc4[nH]c(-c5cn(C)nc5C)nc34)CC2)no1 | Homo sapiens | CHEMBL3889071 | single protein format |
| CHEMBL2207500 |  |
IC50 | = | 30.0 | nM | 413.87 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ncon4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889071 | single protein format |
| CHEMBL3983509 |  |
IC50 | < | 30.0 | nM | 434.92 | C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CO1 | Homo sapiens | CHEMBL3887162 | single protein format |
| CHEMBL2207503 |  |
IC50 | = | 30.0 | nM | 456.38 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889071 | single protein format |
| CHEMBL3891461 |  |
IC50 | = | 30.0 | nM | 481.4 | Cc1nn(C)c(C)c1-c1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1 | Homo sapiens | CHEMBL3889071 | single protein format |
| CHEMBL1201284 |  |
IC50 | = | 50.0 | nM | 357.42 | C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12 | Homo sapiens | CHEMBL3889198 | assay format |
| CHEMBL3973534 |  |
IC50 | = | 65.0 | nM | 452.46 | NC1=N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)COCC[C@H]2CS1 | Homo sapiens | CHEMBL3887162 | single protein format |
| CHEMBL1729 |  |
IC50 | = | 70.0 | nM | 465.95 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL1754 |  |
IC50 | = | 100.0 | nM | 378.52 | CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL1909072 |  |
IC50 | = | 100.0 | nM | 401.96 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL253376 |  |
IC50 | = | 195.8 | nM | 376.14 | CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1 | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL1201193 |  |
IC50 | = | 196.4 | nM | 288.44 | CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL115769 |  |
IC50 | = | 200.0 | nM | 334.35 | COc1cc(N)[nH]c2nc(-c3ccc(F)cc3)c(-c3ccncc3)c1-2 | Homo sapiens | CHEMBL1909136 | cell-based format |
| CHEMBL822 |  |
IC50 | = | 200.0 | nM | 291.44 | CN(C/C=C/C#CC(C)(C)C)Cc1cccc2ccccc12 | Homo sapiens | CHEMBL1909136 | cell-based format |