P10619 | PPGB_HUMAN | Lysosomal protective protein (CTSA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00450 | Peptidase_S10 - Serine carboxypeptidase | 39~476 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha/beta-Hydrolases" // Peptidase_S10 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3913129 |  |
IC50 | = | 2.0 | nM | 436.39 | COc1cccc(OC)c1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL2171390 |  |
IC50 | = | 3.0 | nM | 481.52 | Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(OCC(=O)C(C)(C)C)n(-c2ccccc2F)n1 | Homo sapiens | CHEMBL2176198 | cell-based format |
| CHEMBL3947662 |  |
IC50 | = | 4.0 | nM | 423.44 | COc1ccc(C(C)(C)C#N)cc1-c1cc(F)cc(C(CC(=O)O)c2nnc(C)o2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL2171392 |  |
IC50 | = | 5.0 | nM | 483.54 | Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(OC[C@H](O)C(C)(C)C)n(-c2ccccc2F)n1 | Homo sapiens | CHEMBL2176198 | cell-based format |
| CHEMBL3900996 |  |
IC50 | = | 5.0 | nM | 402.83 | COc1cccc(OC)c1-c1cc(Cl)cc(C(CC(=O)O)c2nnc(C)o2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3959487 |  |
IC50 | = | 5.0 | nM | 401.46 | COc1cccc(OC)c1-c1cc(F)cc(C(CC(=O)O)c2ncc(C)s2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3945914 |  |
IC50 | = | 6.0 | nM | 450.41 | COc1cc(C)cc(OC)c1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3975529 |  |
IC50 | = | 7.0 | nM | 417.91 | COc1cccc(OC)c1-c1cc(Cl)cc(C(CC(=O)O)c2ncc(C)s2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3944726 |  |
IC50 | = | 8.0 | nM | 424.35 | COc1cccc(F)c1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3977104 |  |
IC50 | = | 8.0 | nM | 416.86 | COc1cc(C)cc(OC)c1-c1cc(Cl)cc(C(CC(=O)O)c2nnc(C)o2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3898095 |  |
IC50 | = | 10.0 | nM | 372.81 | COc1ccccc1-c1cc(Cl)cc(C(CC(=O)O)c2nnc(C)o2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL2171394 |  |
IC50 | = | 10.0 | nM | 483.54 | Cc1ccccc1[C@H](CC(=O)O)NC(=O)c1cc(OC[C@@H](O)C(C)(C)C)n(-c2ccccc2F)n1 | Homo sapiens | CHEMBL2176198 | cell-based format |
| CHEMBL3920300 |  |
IC50 | = | 10.0 | nM | 476.45 | COc1ccc2c(c1-c1cc(C(CC(=O)O)c3nnc(C)o3)cc(C(F)(F)F)c1)OC(C)(C)C2 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3907904 |  |
IC50 | = | 11.0 | nM | 383.47 | COc1cccc(OC)c1-c1cccc(C(CC(=O)O)c2ncc(C)s2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3895656 |  |
IC50 | = | 12.0 | nM | 424.35 | COc1ccc(F)cc1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3985600 |  |
IC50 | = | 13.0 | nM | 406.36 | COc1ccccc1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3946844 |  |
IC50 | = | 14.0 | nM | 420.39 | CCOc1ccccc1-c1cc(C(CC(=O)O)c2nnc(C)o2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3980117 |  |
IC50 | = | 14.0 | nM | 401.39 | COc1cc(CO)cc(OC)c1-c1cc(F)cc(C(CC(=O)O)c2ncco2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL3916226 |  |
IC50 | = | 14.0 | nM | 436.39 | COc1ccc(OC)c(-c2cc(C(CC(=O)O)c3nnc(C)o3)cc(C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL3887323 | single protein format |
| CHEMBL2171397 |  |
IC50 | = | 15.0 | nM | 411.43 | CCOc1cc(C(=O)N[C@@H](CC(=O)O)c2ccccc2C)nn1-c1ccccc1F | Homo sapiens | CHEMBL2176198 | cell-based format |