P10586 | PTPRF_HUMAN | Receptor-type tyrosine-protein phosphatase F (PTPRF)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 321~405 | |
| PF00041 | fn3 - Fibronectin type III domain | 415~505 | |
| PF00041 | fn3 - Fibronectin type III domain | 514~598 | |
| PF00041 | fn3 - Fibronectin type III domain | 609~699 | |
| PF00041 | fn3 - Fibronectin type III domain | 711~811 | |
| PF00041 | fn3 - Fibronectin type III domain | 832~904 | |
| PF00041 | fn3 - Fibronectin type III domain | 919~1005 | |
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 1375~1606 | |
| PF00102 | Y_phosphatase - Protein-tyrosine phosphatase | 1664~1897 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 33~124 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 136~216 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 232~315 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL564699 |  |
IC50 | = | 380.0 | nM | 409.57 | CC1(C)SCC(CCCCC(=O)Nc2ccc3c(c2)C[C@@H](C(=O)O)OC3)S1 | Homo sapiens | CHEMBL1054000 | single protein format |
| CHEMBL556636 |  |
IC50 | = | 382.3 | nM | 409.57 | CC1(C)SCC(CCCCC(=O)Nc2ccc3c(c2)CO[C@H](C(=O)O)C3)S1 | Homo sapiens | CHEMBL1054000 | single protein format |
| CHEMBL549372 |  |
IC50 | = | 458.3 | nM | 381.52 | CC1(C)SCC(CCC(=O)Nc2ccc3c(c2)CO[C@H](C(=O)O)C3)S1 | Homo sapiens | CHEMBL1054000 | single protein format |
| CHEMBL556076 |  |
IC50 | = | 493.0 | nM | 381.52 | CC1(C)SCC(CCC(=O)Nc2ccc3c(c2)C[C@@H](C(=O)O)OC3)S1 | Homo sapiens | CHEMBL1054000 | single protein format |
| CHEMBL550662 |  |
IC50 | = | 624.7 | nM | 345.42 | O=C(CCCc1cccs1)Nc1ccc2c(c1)CO[C@H](C(=O)O)C2 | Homo sapiens | CHEMBL1054000 | single protein format |
| CHEMBL200117 |  |
IC50 | = | 690.0 | nM | 569.74 | CCCCCCCCCCCCCCc1ccc(C(=O)c2ccc3c(-c4ccc(OCC(=O)O)cc4)nocc2-3)cc1 | Homo sapiens | CHEMBL865883 | single protein format |
| CHEMBL570779 |  |
IC50 | = | 765.3 | nM | 345.42 | O=C(CCCc1cccs1)Nc1ccc2c(c1)C[C@@H](C(=O)O)OC2 | Homo sapiens | CHEMBL1054000 | single protein format |