P10398 | ARAF_HUMAN | Serine/threonine-protein kinase A-Raf (ARAF)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 99~145 | |
| PF02196 | RBD - Raf-like Ras-binding domain | 20~89 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 311~565 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // RBD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4466555 |  |
IC50 | = | 1.0 | nM | 514.9 | Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 | Homo sapiens | CHEMBL4331428 | single protein format |
| CHEMBL4207519 |  |
IC50 | = | 5.6 | nM | 478.43 | O=C1CCc2c(Oc3ccc4c(c3)[C@H]3[C@@H](O4)[C@@H]3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 | Homo sapiens | CHEMBL4194764 | single protein format |
| CHEMBL1336 |  |
IC50 | = | 7.1 | nM | 464.83 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | Homo sapiens | CHEMBL4050073 | single protein format |
| CHEMBL4438236 |  |
IC50 | = | 8.6 | nM | 513.91 | Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 | Homo sapiens | CHEMBL4331497 | single protein format |
| CHEMBL3934437 |  |
IC50 | < | 10.0 | nM | 456.4 | N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3926189 |  |
IC50 | < | 10.0 | nM | 474.39 | N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3890797 |  |
IC50 | < | 10.0 | nM | 474.39 | N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4c(F)cccc4F)c3F)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3979607 |  |
IC50 | < | 10.0 | nM | 456.4 | N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccc(F)c4)c3F)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3916725 |  |
IC50 | < | 10.0 | nM | 438.42 | N#Cc1cnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)c2c1 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3931676 |  |
IC50 | < | 10.0 | nM | 420.43 | N#Cc1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)c4ccccc4)c3F)c2c1 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3890467 |  |
IC50 | < | 10.0 | nM | 439.4 | N#Cc1ccnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4cccnc4)c3F)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3979361 |  |
IC50 | < | 10.0 | nM | 548.59 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(NS(C)(=O)=O)cc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3942381 |  |
IC50 | < | 10.0 | nM | 500.53 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4cnc(N(C)C)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3899101 |  |
IC50 | < | 10.0 | nM | 465.84 | O=C(c1c(F)ccc(NS(=O)(=O)c2ccccc2F)c1F)c1c[nH]c2nccc(Cl)c12 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3909499 |  |
IC50 | < | 10.0 | nM | 499.5 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(C(N)=O)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3897700 |  |
IC50 | < | 10.0 | nM | 498.56 | CCCc1ccc(-c2cnc3[nH]cc(C(=O)c4c(F)ccc(NS(=O)(=O)CCC)c4F)c3c2)cn1 | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3919966 |  |
IC50 | < | 10.0 | nM | 525.58 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(N5CCCC5)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3917210 |  |
IC50 | < | 10.0 | nM | 585.63 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCN5CCOCC5)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3958968 |  |
IC50 | < | 10.0 | nM | 569.63 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(OCCN5CCCC5)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |
| CHEMBL3961672 |  |
IC50 | < | 10.0 | nM | 472.47 | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(O)nc4)cc23)c1F | Homo sapiens | CHEMBL3880148 | single protein format |