P10276 | RARA_HUMAN | Retinoic acid receptor alpha (RARA)

Pfam Domain Table

AccessionDomainRangeColor
PF00104Hormone_recep - Ligand-binding domain of nuclear hormone receptor227~399
PF00105zf-C4 - Double treble clef zinc finger, C4 type87~155

3D structures mapped by conservation among orthologs

[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]

 PyMOL session

[ Domain: "LIM domain-like" // zf-C4 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL134375 IC50 = 0.45 nM 373.5 CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL38 IC50 = 0.89 nM 300.44 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799873 single protein format
CHEMBL133725 IC50 = 2.2 nM 375.47 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL131850 IC50 = 2.4 nM 392.52 CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)cs3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL705 IC50 = 7.0 nM 300.44 CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799871 single protein format
CHEMBL550796 IC50 = 15.0 nM 380.48 CC(=C\c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C)/C=C(\C)C(=O)O Homo sapiens CHEMBL1063213 single protein format
CHEMBL131925 IC50 = 19.0 nM 376.46 CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)co3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL132033 IC50 = 32.0 nM 376.46 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)o3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL275311 IC50 = 36.0 nM 348.49 C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL432592 IC50 = 40.0 nM 353.42 CC1(C)CCC(C)(C)c2nc(C(=O)Nc3ccc(C(=O)O)cc3)cnc21 Homo sapiens CHEMBL799793 single protein format
CHEMBL69367 IC50 = 41.0 nM 351.45 CC1(C)CCC(C)(C)c2cc(C(=O)Nc3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL25202 IC50 = 78.0 nM 351.45 CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL799791 single protein format
CHEMBL336311 IC50 = 83.0 nM 393.51 CC1(C)CCC(C)(C)c2nc(-c3csc(-c4ccc(C(=O)O)cc4)n3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL284937 IC50 = 100.0 nM 376.54 CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL472172 IC50 = 114.0 nM 404.51 CC1(C)CC=C(C#Cc2ccccc2)c2cc(/C=C/c3ccc(C(=O)O)cc3)ccc21 Homo sapiens CHEMBL3118431 single protein format
CHEMBL131810 IC50 = 130.0 nM 392.52 CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)s3)cnc21 Homo sapiens CHEMBL799792 single protein format
CHEMBL32505 IC50 = 638.0 nM 362.51 C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C Homo sapiens CHEMBL799871 single protein format
CHEMBL38 Ki = 0.1 nM 300.44 CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 Homo sapiens CHEMBL799977 single protein format
CHEMBL74331 Ki = 3.1 nM 314.47 CC(/C=C/C1CC1/C=C/C1=CC(C)(C)CCC1(C)C)=C\C(=O)O Homo sapiens CHEMBL799977 single protein format
CHEMBL36768 Ki = 5.3 nM 358.48 CC1(C)CCC(C)(C)c2cc3cc(-c4ccc(C(=O)O)cc4)ccc3cc21 Homo sapiens CHEMBL799802 single protein format