P10276 | RARA_HUMAN | Retinoic acid receptor alpha (RARA)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 227~399 | |
PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 87~155 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Domain: "LIM domain-like" // zf-C4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL134375 | IC50 | = | 0.45 | nM | 373.5 | CC1(C)CCC(C)(C)c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)ccc21 | Homo sapiens | CHEMBL799791 | single protein format | |
CHEMBL38 | IC50 | = | 0.89 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL799873 | single protein format | |
CHEMBL133725 | IC50 | = | 2.2 | nM | 375.47 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)[nH]3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL131850 | IC50 | = | 2.4 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)cs3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL705 | IC50 | = | 7.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL799871 | single protein format | |
CHEMBL550796 | IC50 | = | 15.0 | nM | 380.48 | CC(=C\c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C)/C=C(\C)C(=O)O | Homo sapiens | CHEMBL1063213 | single protein format | |
CHEMBL131925 | IC50 | = | 19.0 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3cc(-c4ccc(C(=O)O)cc4)co3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL132033 | IC50 | = | 32.0 | nM | 376.46 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)o3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL275311 | IC50 | = | 36.0 | nM | 348.49 | C/C(=C\c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799871 | single protein format | |
CHEMBL432592 | IC50 | = | 40.0 | nM | 353.42 | CC1(C)CCC(C)(C)c2nc(C(=O)Nc3ccc(C(=O)O)cc3)cnc21 | Homo sapiens | CHEMBL799793 | single protein format | |
CHEMBL69367 | IC50 | = | 41.0 | nM | 351.45 | CC1(C)CCC(C)(C)c2cc(C(=O)Nc3ccc(C(=O)O)cc3)ccc21 | Homo sapiens | CHEMBL799791 | single protein format | |
CHEMBL25202 | IC50 | = | 78.0 | nM | 351.45 | CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(C(=O)O)cc3)ccc21 | Homo sapiens | CHEMBL799791 | single protein format | |
CHEMBL336311 | IC50 | = | 83.0 | nM | 393.51 | CC1(C)CCC(C)(C)c2nc(-c3csc(-c4ccc(C(=O)O)cc4)n3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL284937 | IC50 | = | 100.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799871 | single protein format | |
CHEMBL472172 | IC50 | = | 114.0 | nM | 404.51 | CC1(C)CC=C(C#Cc2ccccc2)c2cc(/C=C/c3ccc(C(=O)O)cc3)ccc21 | Homo sapiens | CHEMBL3118431 | single protein format | |
CHEMBL131810 | IC50 | = | 130.0 | nM | 392.52 | CC1(C)CCC(C)(C)c2nc(-c3ccc(-c4ccc(C(=O)O)cc4)s3)cnc21 | Homo sapiens | CHEMBL799792 | single protein format | |
CHEMBL32505 | IC50 | = | 638.0 | nM | 362.51 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL799871 | single protein format | |
CHEMBL38 | Ki | = | 0.1 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL799977 | single protein format | |
CHEMBL74331 | Ki | = | 3.1 | nM | 314.47 | CC(/C=C/C1CC1/C=C/C1=CC(C)(C)CCC1(C)C)=C\C(=O)O | Homo sapiens | CHEMBL799977 | single protein format | |
CHEMBL36768 | Ki | = | 5.3 | nM | 358.48 | CC1(C)CCC(C)(C)c2cc3cc(-c4ccc(C(=O)O)cc4)ccc3cc21 | Homo sapiens | CHEMBL799802 | single protein format |