P10253 | LYAG_HUMAN | Lysosomal alpha-glucosidase (GAA)

Pfam Domain Table

AccessionDomainRangeColor
PF00088Trefoil - Trefoil (P-type) domain82~130
PF01055Glyco_hydro_31_2nd - Glycosyl hydrolases family 31 TIM-barrel domain361~712
PF13802Gal_mutarotas_2 - Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain162~318
PF21365Glyco_hydro_31_3rd - Glycosyl hydrolase family 31 C-terminal domain720~824

3D structures mapped by conservation among orthologs

[ Domain: "Glycosyl hydrolase domain" // Glyco_hydro_31_C ]

 PyMOL session

[ Domain: "supersandwich" // Gal_mutarotas_2 ]

 PyMOL session

[ Domain: "supersandwich" // Gal_mutarotas_2,Trefoil ]

 PyMOL session

[ Domain: "Putative glucosidase YicI, C-terminal domain" // DUF5110_1 ]

 PyMOL session

[ Domain: "TIM barrels" // Glyco_hydro_31_N ]

 PyMOL session

[ Domain: "Trefoil/Plexin domain-like" // Trefoil ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL86772 IC50 = 10.3 nM 280.28 OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O Homo sapiens CHEMBL647267 single protein format
CHEMBL476960 IC50 = 70.0 nM 267.28 OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL993579 cell-based format
CHEMBL1029 IC50 = 100.0 nM 219.28 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO Homo sapiens CHEMBL1040324 single protein format
CHEMBL5429566 IC50 = 250.0 nM 495.54 O=C(O)C(F)(F)F.OC[C@H]1N[C@H](CCCCCCCCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5320878 subcellular format
CHEMBL1561 IC50 = 350.0 nM 207.23 OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO Homo sapiens CHEMBL993567 single protein format
CHEMBL574645 IC50 = 400.0 nM 397.56 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 Homo sapiens CHEMBL1040324 single protein format
CHEMBL88413 IC50 = 402.0 nM 179.17 NC1C(O)C(O)C(O)C1(O)CO Homo sapiens CHEMBL647267 single protein format
CHEMBL1088158 IC50 = 500.0 nM 397.56 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 Homo sapiens CHEMBL1099885 single protein format
CHEMBL2177695 IC50 = 600.0 nM 275.39 CCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL5320878 subcellular format
CHEMBL5189075 IC50 = 630.0 nM 209.25 OC[C@]1(c2ccccc2)NC[C@H](O)[C@H]1O Homo sapiens CHEMBL5135397 single protein format
CHEMBL1603014 IC50 = 940.0 nM 399.47 CC(=O)c1ccc(N2CCN(S(=O)(=O)c3ccc4c(c3)CC(=O)N4)CC2)cc1 Homo sapiens CHEMBL2183407 single protein format
CHEMBL307429 IC50 = 1000.0 nM 163.17 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL993567 single protein format
CHEMBL501355 IC50 = 1000.0 nM 193.2 OC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Homo sapiens CHEMBL993567 single protein format
CHEMBL5028005 Ki = 4.7 nM 261.36 CCCCCCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5041858 single protein format
CHEMBL5028265 Ki = 6.1 nM 247.33 CCCCCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5041858 single protein format
CHEMBL5029066 Ki = 19.0 nM 233.31 CCCCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5041858 single protein format
CHEMBL5027974 Ki = 37.0 nM 219.28 CCCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5041858 single protein format
CHEMBL5028138 Ki = 59.0 nM 205.25 CCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O Homo sapiens CHEMBL5041858 single protein format
CHEMBL1651551 Ki = 95.0 nM 261.36 CCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO Homo sapiens CHEMBL5041858 single protein format
CHEMBL1651550 Ki = 130.0 nM 247.33 CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO Homo sapiens CHEMBL5041858 single protein format