P10242 | MYB_HUMAN | Transcriptional activator Myb (MYB)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00249 | Myb_DNA-binding | 40–86 | |
| PF00249 | Myb_DNA-binding | 92–138 | |
| PF00249 | Myb_DNA-binding | 144–187 | |
| PF07988 | LMSTEN | 268–313 | |
| PF09316 | Cmyb_C | 398–556 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL321336 |  |
IC50 | = | 8.7 | nM | 343.34 | N#CC1=C(N)Oc2c(ccc3ccccc23)C1c1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL228363 |  |
IC50 | = | 9.1 | nM | 388.42 | COc1cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc(OC)c1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5188413 |  |
IC50 | = | 11.0 | nM | 412.45 | C#CCOc1c(OC)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5184353 |  |
IC50 | = | 14.0 | nM | 402.45 | CCOc1c(OC)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5198083 |  |
IC50 | = | 14.0 | nM | 414.46 | C=CCOc1c(OC)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL4442805 |  |
IC50 | = | 16.0 | nM | 350.78 | N#CC1=C(N)Oc2c(ccc3ccccc23)C1c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5176572 |  |
IC50 | = | 30.0 | nM | 430.5 | CCCCOc1c(OC)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5176963 |  |
IC50 | = | 30.0 | nM | 416.48 | CCCOc1c(OC)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5198730 |  |
IC50 | = | 36.8 | nM | 451.32 | CCOc1c(Br)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL591374 |  |
IC50 | = | 40.0 | nM | 358.4 | COc1ccc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5192004 |  |
IC50 | = | 50.0 | nM | 498.32 | CCOc1c(I)cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5203253 |  |
IC50 | = | 60.0 | nM | 416.48 | COc1cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc(OC)c1OC(C)C | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5192001 |  |
IC50 | = | 70.0 | nM | 352.31 | N#CC1=C(N)Oc2c(ccc3ccccc23)C1c1cc(F)c(F)c(F)c1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5173047 |  |
IC50 | = | 110.0 | nM | 373.37 | COc1ccc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1[N+](=O)[O-] | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL4436683 |  |
IC50 | = | 130.0 | nM | 424.39 | N#CC1=C(N)Oc2c(ccc3ccccc23)C1c1cccc(S(F)(F)(F)(F)F)c1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5194887 |  |
IC50 | = | 130.0 | nM | 467.32 | COc1cc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)c(Br)c(OC)c1OC | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL4441682 |  |
IC50 | = | 210.0 | nM | 344.44 | CSc1ccc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5187002 |  |
IC50 | = | 240.0 | nM | 362.43 | CSc1ccc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1F | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL4567907 |  |
IC50 | = | 390.0 | nM | 323.36 | N#CC1=C(N)Oc2c(ccc3ccccc23)C1c1ccc(C#N)cc1 | Homo sapiens | CHEMBL5131351 | cell-based format |
| CHEMBL5188662 |  |
IC50 | = | 400.0 | nM | 342.4 | COc1ccc(C2C(C#N)=C(N)Oc3c2ccc2ccccc32)cc1C | Homo sapiens | CHEMBL5131351 | cell-based format |