P10145 | IL8_HUMAN | Interleukin-8 (CXCL8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00048 | IL8 - Small cytokines (intecrine/chemokine), interleukin-8 like | 33~91 |
3D structures mapped by conservation among orthologs
[ Domain: "IL8" // IL8_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL139 |  |
IC50 | = | 8.0 | nM | 296.15 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL427739 |  |
IC50 | = | 9.0 | nM | 245.25 | O=C(O)Cc1ccccc1Nc1ccccc1F | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL570538 |  |
IC50 | = | 10.0 | nM | 310.18 | CC(C(=O)O)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL553416 |  |
IC50 | = | 12.0 | nM | 309.2 | CC(C(N)=O)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL549974 |  |
IC50 | = | 13.0 | nM | 387.29 | CC(C(=O)NS(C)(=O)=O)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL29804 |  |
IC50 | = | 13.0 | nM | 246.24 | O=C(O)Cc1ccccc1Oc1ccccc1F | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL372052 |  |
IC50 | = | 20.0 | nM | 254.29 | C[C@@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1 | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL552258 |  |
IC50 | = | 20.0 | nM | 353.25 | CC(C(=O)NCCO)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL77981 |  |
IC50 | = | 25.0 | nM | 296.15 | O=C(O)Cc1ccccc1Nc1cc(Cl)ccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL569366 |  |
IC50 | = | 25.0 | nM | 394.35 | CC(C(=O)NCCCN(C)C)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL6 |  |
IC50 | = | 50.0 | nM | 357.79 | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL549973 |  |
IC50 | = | 50.0 | nM | 323.35 | CS(=O)(=O)NC(=O)Cc1ccccc1Oc1ccccc1F | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL427526 |  |
IC50 | = | 50.0 | nM | 206.28 | CC(C)Cc1ccc([C@@H](C)C(=O)O)cc1 | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL1020 |  |
IC50 | = | 90.0 | nM | 257.29 | Cc1ccc(C(=O)c2ccc(CC(=O)O)n2C)cc1 | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL77823 |  |
IC50 | = | 400.0 | nM | 261.71 | O=C(O)Cc1ccccc1Nc1ccccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL30038 |  |
IC50 | = | 500.0 | nM | 262.69 | O=C(O)Cc1ccccc1Oc1ccccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL541236 |  |
IC50 | = | 500.0 | nM | 310.18 | Cc1ccc(Cl)c(Nc2ccccc2CC(=O)O)c1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL559389 |  |
IC50 | = | 600.0 | nM | 413.35 | Cc1cccc(C)c1NC(=O)C(C)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |
| CHEMBL549975 |  |
IC50 | = | 650.0 | nM | 365.3 | CC(C(=O)NC(C)(C)C)c1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1052371 | single protein format |