P10144 | GRAB_HUMAN | Granzyme B (GZMB)

Pfam Domain Table

AccessionDomainRangeColor
PF00089Trypsin - Trypsin21~240

3D structures mapped by conservation among orthologs

[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL304368 Ki = 8.0 nM 500.55 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@H](C=O)C(=O)O)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format
CHEMBL428244 Ki = 8.0 nM 500.55 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@H](C=O)CC(=O)O)C3 Homo sapiens CHEMBL948945 single protein format
CHEMBL71493 Ki = 13.0 nM 556.67 CC[C@H](C)[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCc1cn[nH]c1)C3 Homo sapiens CHEMBL684582 single protein format
CHEMBL305293 Ki = 13.0 nM 474.51 CC[C@H](C)[C@H](NC(C)=O)C(=O)NCC(=O)N1c2ccccc2C[C@H]1C(=O)N[C@H](C=O)CC(=O)O Homo sapiens CHEMBL684582 single protein format
CHEMBL303031 Ki = 16.0 nM 572.62 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)C(=O)OC)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format
CHEMBL306381 Ki = 38.0 nM 495.58 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCc1cn[nH]n1)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format
CHEMBL303944 Ki = 74.0 nM 496.57 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCc1nn[nH]n1)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format
CHEMBL304727 Ki = 75.0 nM 487.56 CC(C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCc1cn[nH]n1)C3)c1ccccn1 Homo sapiens CHEMBL684582 single protein format
CHEMBL70602 Ki = 80.0 nM 498.53 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CC(=O)O Homo sapiens CHEMBL684582 single protein format
CHEMBL71937 Ki = 122.0 nM 452.51 CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@H]1CC[C@H]2CC[C@@H](C(=O)N[C@H](C=O)CC(=O)O)N2C1=O Homo sapiens CHEMBL684582 single protein format
CHEMBL69482 Ki = 133.0 nM 422.44 CC[C@H](C)[C@H](NC(C)=O)C(=O)Nc1cccn(CC(=O)N[C@H](C=O)CC(=O)O)c1=O Homo sapiens CHEMBL684582 single protein format
CHEMBL69424 Ki = 270.0 nM 426.47 CC[C@H](C)[C@H](NC(C)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CC(=O)O Homo sapiens CHEMBL684582 single protein format
CHEMBL305418 Ki = 360.0 nM 511.58 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCc1cc(O)no1)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format
CHEMBL306449 Ki = 580.0 nM 486.57 CC[C@H](C)[C@@H](C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@H](C(=O)NCCC(=O)O)C3)N(C)C(C)=O Homo sapiens CHEMBL684582 single protein format