P0DMS9 | TMIG3_HUMAN | Transmembrane domain-containing protein TMIGD3 (TMIGD3)
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL344187 |  |
IC50 | = | 42.0 | nM | 522.3 | O=C1NCC[C@@]12O[C@@H](n1cnc3c(NCc4cccc(I)c4)ncnc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3772111 | cell-based format |
| CHEMBL4068878 |  |
IC50 | = | 73.0 | nM | 420.47 | COc1ccc(C(=O)Nc2nc(-c3ccccc3)cn3cc(-c4ccccc4)nc23)cc1 | Homo sapiens | CHEMBL4041938 | cell-based format |
| CHEMBL4092103 |  |
IC50 | = | 163.0 | nM | 314.35 | O=C(Nc1nccn2cc(-c3ccccc3)nc12)c1ccccc1 | Homo sapiens | CHEMBL4041938 | cell-based format |
| CHEMBL4069012 |  |
IC50 | = | 172.0 | nM | 391.43 | O=C(Nc1nc(-c2ccccc2)cn2cc(-c3ccccc3)nc12)c1cccnc1 | Homo sapiens | CHEMBL4041938 | cell-based format |
| CHEMBL4070079 |  |
IC50 | = | 187.0 | nM | 418.46 | O=C(c1ccccc1)N(C(=O)c1ccccc1)c1nccn2cc(-c3ccccc3)nc12 | Homo sapiens | CHEMBL4041938 | cell-based format |
| CHEMBL4075640 |  |
IC50 | = | 235.0 | nM | 390.45 | O=C(Nc1nc(-c2ccccc2)cn2cc(-c3ccccc3)nc12)c1ccccc1 | Homo sapiens | CHEMBL4041938 | cell-based format |
| CHEMBL3747303 |  |
Ki | = | 0.54 | nM | 359.35 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(N=[N+]=[N-])nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746778 |  |
Ki | = | 0.58 | nM | 546.41 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccc(Br)s5)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746260 |  |
Ki | = | 0.69 | nM | 373.38 | CCNc1nc(N=[N+]=[N-])nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12 | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3612943 |  |
Ki | = | 0.73 | nM | 501.96 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccc(Cl)s5)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3747209 |  |
Ki | = | 0.85 | nM | 449.48 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(N=[N+]=[N-])nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3747005 |  |
Ki | = | 0.85 | nM | 399.42 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCC4)nc(N=[N+]=[N-])nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746512 |  |
Ki | = | 0.91 | nM | 534.36 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCCc4ccccc4)nc(I)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746774 |  |
Ki | = | 0.95 | nM | 495.93 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccccc5Cl)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746358 |  |
Ki | = | 0.96 | nM | 461.49 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccccc5)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3747276 |  |
Ki | = | 0.96 | nM | 451.45 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccco5)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3747457 |  |
Ki | = | 1.06 | nM | 497.47 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(-n4cc(-c5ccc(F)c(F)c5)nn4)nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3746487 |  |
Ki | = | 1.08 | nM | 469.89 | CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NCc4cccc(Cl)c4)nc(N=[N+]=[N-])nc31)[C@H](O)[C@@H]2O | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3747461 |  |
Ki | = | 1.22 | nM | 458.26 | CCNc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12 | Homo sapiens | CHEMBL3749019 | cell-based format |
| CHEMBL3612944 |  |
Ki | = | 1.22 | nM | 515.99 | CCNc1nc(-n2cc(-c3ccc(Cl)s3)nn2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12 | Homo sapiens | CHEMBL3749019 | cell-based format |