P09917 | LOX5_HUMAN | Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00305 | Lipoxygenase - Lipoxygenase | 222~658 | |
| PF01477 | PLAT - PLAT/LH2 domain | 4~112 |
3D structures mapped by conservation among orthologs
[ Domain: "Lipase/lipooxygenase domain (PLAT/LH2 domain)" // PLAT ]
[ Domain: "Lipase/lipooxygenase domain (PLAT/LH2 domain)" // PLAT,RNAse_Pc_like ]
[ Domain: "Lipoxygenase" // Lipoxygenase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL16596 |  |
IC50 | = | 1.6 | nM | 587.19 | CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 | Homo sapiens | CHEMBL3118900 | single protein format |
| CHEMBL423638 |  |
IC50 | = | 3.0 | nM | 536.63 | COC1(c2cc(F)cc(OCc3cc(-c4ccccc4)n(-c4ccc(S(C)(=O)=O)cc4)n3)c2)CCOCC1 | Homo sapiens | CHEMBL618018 | assay format |
| CHEMBL3238463 |  |
IC50 | = | 4.0 | nM | 337.29 | O=C(Nc1cccc2ccccc12)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL3240356 | single protein format |
| CHEMBL3238207 |  |
IC50 | = | 6.0 | nM | 302.24 | Cc1cccc(OC(=O)c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)c1 | Homo sapiens | CHEMBL3240356 | single protein format |
| CHEMBL5421129 |  |
IC50 | = | 7.0 | nM | 292.36 | Oc1ccc(-c2cccc3c2sc2ccccc23)cc1O | Homo sapiens | CHEMBL5354820 | assay format |
| CHEMBL5398068 |  |
IC50 | = | 7.0 | nM | 236.27 | Oc1ccc(-c2ccc3ccccc3c2)cc1O | Homo sapiens | CHEMBL5354820 | assay format |
| CHEMBL1290649 |  |
IC50 | = | 7.9 | nM | 475.49 | CCC(O)(c1cn(Cc2ccc3c(-c4ccccc4)c(C(=O)OC)sc3c2)nn1)C(F)(F)F | Homo sapiens | CHEMBL1290999 | single protein format |
| CHEMBL5395696 |  |
IC50 | = | 8.0 | nM | 326.44 | Oc1ccc(-c2cccc3c2SC2C=CC=CC2S3)cc1O | Homo sapiens | CHEMBL5354820 | assay format |
| CHEMBL3113612 |  |
IC50 | = | 8.0 | nM | 414.44 | COC(=O)CNC(=O)C(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12 | Homo sapiens | CHEMBL3118899 | assay format |
| CHEMBL3113617 |  |
IC50 | = | 8.6 | nM | 400.41 | Cc1ccc(S(=O)(=O)n2cc(C(=O)C(=O)NCC(=O)O)c3ccccc32)cc1 | Homo sapiens | CHEMBL3118900 | single protein format |
| CHEMBL377094 |  |
IC50 | = | 9.0 | nM | 504.38 | O=c1cc(-c2ccoc2)c2ccc(Sc3cc(F)cc(C(O)(C(F)(F)F)C(F)(F)F)c3)cc2o1 | Homo sapiens | CHEMBL870097 | single protein format |
| CHEMBL5413117 |  |
IC50 | = | 10.0 | nM | 280.32 | CCOc1ccc2ccccc2c1-c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL5354820 | assay format |
| CHEMBL3238465 |  |
IC50 | = | 10.0 | nM | 301.26 | Cc1cccc(NC(=O)c2cc([N+](=O)[O-])cc([N+](=O)[O-])c2)c1 | Homo sapiens | CHEMBL3240356 | single protein format |
| CHEMBL5401317 |  |
IC50 | = | 10.0 | nM | 286.33 | Oc1ccc(-c2c3ccccc3cc3ccccc23)cc1O | Homo sapiens | CHEMBL5354820 | assay format |
| CHEMBL88084 |  |
IC50 | = | 10.0 | nM | 348.44 | COC1(c2cccc(OCc3ccc4ccccc4c3)c2)CCOCC1 | Homo sapiens | CHEMBL619885 | single protein format |
| CHEMBL3113618 |  |
IC50 | = | 10.0 | nM | 529.57 | Cc1ccc(S(=O)(=O)n2cc(C(=O)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)O)c3ccccc32)cc1 | Homo sapiens | CHEMBL3118900 | single protein format |
| CHEMBL1289215 |  |
IC50 | = | 11.0 | nM | 459.49 | CCC(O)(c1cn(Cc2ccc3c(-c4ccccc4)c(C(C)=O)sc3c2)nn1)C(F)(F)F | Homo sapiens | CHEMBL1290999 | single protein format |
| CHEMBL5290007 |  |
IC50 | = | 12.73 | nM | 318.46 | C=C1CCCC2C1(C)CCC(C)C2(C)CCC1=CC(=O)OC1O | Homo sapiens | CHEMBL5242614 | single protein format |
| CHEMBL129292 |  |
IC50 | = | 14.0 | nM | 480.56 | COC1(c2cccc(COc3ccc4c(-c5ccccc5)c5c(cc4c3)C(=O)OC5)c2)CCOCC1 | Homo sapiens | CHEMBL618012 | single protein format |
| CHEMBL3113613 |  |
IC50 | = | 14.0 | nM | 543.6 | COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(=O)c1cn(S(=O)(=O)c2ccc(C)cc2)c2ccccc12 | Homo sapiens | CHEMBL3118899 | assay format |