P09874 | PARP1_HUMAN | Poly [ADP-ribose] polymerase 1 (PARP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00533 | BRCT - BRCA1 C Terminus (BRCT) domain | 387~461 | |
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 808~1007 | |
| PF00645 | zf-PARP - Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region | 12~88 | |
| PF00645 | zf-PARP - Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region | 116~199 | |
| PF02877 | PARP_reg - Poly(ADP-ribose) polymerase, regulatory domain | 663~794 | |
| PF05406 | WGR - WGR domain | 554~630 | |
| PF08063 | Zn_ribbon_PADR1 - PADR1 domain, zinc ribbon fold | 291~331 | |
| PF21728 | PADR1_N - PADR1, N-terminal helical domain | 231~290 |
3D structures mapped by conservation among orthologs
[ Domain: "LEM/SAP HeH motif" // PLN03123 ]
[ Domain: "LEM/SAP HeH motif" // PADR1,PLN03123 ]
[ Domain: "Domain of poly(ADP-ribose) polymerase" // PARP_reg ]
[ Domain: "WGR domain" // WGR ]
[ Domain: "ADP-ribosylation" // PARP ]
[ Domain: "BRCT domain" // PTCB-BRCT ]
[ Domain: "Rubredoxin-related" // PADR1 ]
[ Domain: "PARP-type zinc finger" // zf-PARP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | < | 0.001 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL5437176 |  |
IC50 | < | 0.001 | nM | 498.52 | Cc1cc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)oc1C | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL4169012 |  |
IC50 | = | 0.02 | nM | 485.49 | N#Cc1ccccc1N1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)cc(F)c2F)CC1 | Homo sapiens | CHEMBL4131013 | single protein format |
| CHEMBL5401127 |  |
IC50 | = | 0.02 | nM | 585.67 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCSCC3)o2)C1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL5396891 |  |
IC50 | = | 0.023 | nM | 522.36 | NC(=O)c1cccc2[nH]c(-c3ccc(C(=O)N4CCN(C(=O)c5ccc(Br)o5)CC4)cc3)nc12 | Homo sapiens | CHEMBL5362173 | single protein format |
| CHEMBL4170665 |  |
IC50 | = | 0.1 | nM | 461.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2ccccn2)CC1 | Homo sapiens | CHEMBL4131013 | single protein format |
| CHEMBL5425913 |  |
IC50 | < | 0.1 | nM | 583.81 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2cc(Br)c(Cl)o2)C1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL4161087 |  |
IC50 | < | 0.1 | nM | 474.51 | Cc1ccc(N2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)cc(F)c3F)CC2)cc1 | Homo sapiens | CHEMBL4131013 | single protein format |
| CHEMBL5425729 |  |
IC50 | = | 0.17 | nM | 567.63 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(CN3CCCCC3)o2)C1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL5403789 |  |
IC50 | = | 0.175 | nM | 450.47 | O=C(c1cc(Cc2n[nH]c(=O)c3cccc(O)c23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL5329523 | cell-based format |
| CHEMBL4845834 |  |
IC50 | = | 0.19 | nM | 482.52 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(c2nc3ccccc3[nH]2)CC1 | Homo sapiens | CHEMBL4823042 | single protein format |
| CHEMBL4159834 |  |
IC50 | = | 0.2 | nM | 467.5 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)cc(F)c1F)N1CCN(c2nccs2)CC1 | Homo sapiens | CHEMBL4131013 | single protein format |
| CHEMBL3933136 |  |
IC50 | = | 0.2 | nM | 346.79 | Cc1cc(-c2[nH]c(=O)c3cc(F)ccc3c2OCCN)ccc1Cl | Homo sapiens | CHEMBL3888857 | cell-based format |
| CHEMBL4867855 |  |
IC50 | = | 0.23 | nM | 525.54 | NC(=O)c1cncc2[nH]c(C3CCN(C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)CC3)nc12 | Homo sapiens | CHEMBL4823042 | single protein format |
| CHEMBL5404605 |  |
IC50 | = | 0.23 | nM | 495.47 | N#Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL5428376 |  |
IC50 | = | 0.24 | nM | 484.49 | Cc1ccc(-c2nnc3n2CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)o1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL5416841 |  |
IC50 | = | 0.25 | nM | 425.28 | NC(=O)c1ccccc1OCc1cccc(NC(=O)c2ccc(Br)cc2)c1 | Homo sapiens | CHEMBL5349315 | single protein format |
| CHEMBL5425393 |  |
IC50 | = | 0.26 | nM | 470.46 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccco2)C1 | Homo sapiens | CHEMBL5366416 | single protein format |
| CHEMBL2322618 |  |
IC50 | = | 0.31 | nM | 468.49 | O=C1NCC2c3c(cccc31)CCN2C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F | Homo sapiens | CHEMBL2330729 | single protein format |
| CHEMBL5180001 |  |
IC50 | = | 0.34 | nM | 432.53 | CCc1cc2ncc(CN3CC4CN(c5ccc(C(=O)NC)nc5)CC4C3)cc2[nH]c1=O | Homo sapiens | CHEMBL5152892 | single protein format |