P09619 | PGFRB_HUMAN | Platelet-derived growth factor receptor beta (PDGFRB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00047 | ig - Immunoglobulin domain | 40~110 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 601~955 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 217~294 | |
| PF25305 | Ig_PDGFR_d4 - Platelet-derived growth factor receptor Ig-like domain 4 | 418~556 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_12 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL526507 |  |
IC50 | = | 0.1 | nM | 507.6 | CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(C(=O)NCc6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL495749 |  |
IC50 | = | 0.1 | nM | 389.46 | CN1CCCC(Oc2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)C1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL2023477 |  |
IC50 | = | 0.2 | nM | 463.49 | COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL2023485 |  |
IC50 | = | 0.2 | nM | 462.51 | CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)n[nH]1 | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL495984 |  |
IC50 | = | 0.2 | nM | 401.51 | CCC1CCN(C)C(Nc2c(-c3nc4ccccc4[nH]3)c(=O)[nH]c3ccccc23)C1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL1940109 |  |
IC50 | = | 0.3 | nM | 479.49 | COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC | Homo sapiens | CHEMBL1942929 | cell-based format |
| CHEMBL498551 |  |
IC50 | = | 0.3 | nM | 374.45 | CN1CCN(c2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)CC1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL495762 |  |
IC50 | = | 0.3 | nM | 408.89 | CN1CCN(c2ccc3[nH]c(-c4c(N)c5c(Cl)cccc5[nH]c4=O)nc3c2)CC1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL2023476 |  |
IC50 | = | 0.3 | nM | 435.51 | COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1 | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL498013 |  |
IC50 | = | 0.4 | nM | 392.44 | CN1CCN(c2ccc3[nH]c(-c4c(N)c5ccc(F)cc5[nH]c4=O)nc3c2)CC1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL2023482 |  |
IC50 | = | 0.4 | nM | 433.46 | CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1 | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL1940273 |  |
IC50 | = | 0.4 | nM | 432.48 | CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cn1 | Homo sapiens | CHEMBL1942929 | cell-based format |
| CHEMBL2347053 |  |
IC50 | = | 0.4 | nM | 332.32 | O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] | Homo sapiens | CHEMBL2350672 | single protein format |
| CHEMBL13976 |  |
IC50 | = | 0.5 | nM | 370.43 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN(C)C | Homo sapiens | CHEMBL768949 | single protein format |
| CHEMBL2023486 |  |
IC50 | = | 0.5 | nM | 432.48 | CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)n[nH]1 | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL495735 |  |
IC50 | = | 0.6 | nM | 479.59 | CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(NCc6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL2023118 |  |
IC50 | = | 0.7 | nM | 432.48 | CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1 | Homo sapiens | CHEMBL2027405 | single protein format |
| CHEMBL495763 |  |
IC50 | = | 0.7 | nM | 388.48 | Cc1cccc2[nH]c(=O)c(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c(N)c12 | Homo sapiens | CHEMBL1011001 | single protein format |
| CHEMBL1940108 |  |
IC50 | = | 0.8 | nM | 435.44 | COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1 | Homo sapiens | CHEMBL1942929 | cell-based format |
| CHEMBL1940259 |  |
IC50 | = | 0.9 | nM | 445.48 | COc1cccc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 | Homo sapiens | CHEMBL1942929 | cell-based format |