P09467 | F16P1_HUMAN | Fructose-1,6-bisphosphatase 1 (FBP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00316 | FBPase - Fructose-1-6-bisphosphatase, N-terminal domain | 13~198 | |
| PF18913 | FBPase_C - Fructose-1-6-bisphosphatase, C-terminal domain | 203~332 |
3D structures mapped by conservation among orthologs
[ Domain: "a+b domain in carbohydrate phosphatases" // FBPase_N ]
[ Domain: "Rossmann-like domain in carbohydrate phosphatases" // FBPase_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1173125 |  |
IC50 | = | 1.0 | nM | 524.54 | CCOC(=O)[C@H](C)NP(=O)(COc1ccc(C(N)=O)c2c1-c1ncsc1C2)N[C@@H](C)C(=O)OCC | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL589266 |  |
IC50 | = | 1.0 | nM | 326.27 | NC(=O)c1ccc(OCP(=O)(O)O)c2c1Cc1scnc1-2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL1173126 |  |
IC50 | = | 2.0 | nM | 538.56 | CCOC(=O)[C@H](C)NP(=O)(COc1ccc(C(=O)NC)c2c1-c1ncsc1C2)N[C@@H](C)C(=O)OCC | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL597891 |  |
IC50 | = | 2.0 | nM | 340.3 | CNC(=O)c1ccc(OCP(=O)(O)O)c2c1Cc1scnc1-2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL597692 |  |
IC50 | = | 3.0 | nM | 361.32 | O=P(O)(O)COc1ccc(-c2cncnc2)c2c1-c1ncsc1C2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL462979 |  |
IC50 | = | 3.0 | nM | 530.63 | Cc1cccc(S(=O)(=O)NC(=O)NCc2ccc(CNC(=O)NS(=O)(=O)c3cccc(C)c3)cc2)c1 | Homo sapiens | CHEMBL974537 | assay format |
| CHEMBL462978 |  |
IC50 | = | 6.0 | nM | 571.46 | O=C(NCc1ccc(CNC(=O)NS(=O)(=O)c2cccc(Cl)c2)cc1)NS(=O)(=O)c1cccc(Cl)c1 | Homo sapiens | CHEMBL974537 | assay format |
| CHEMBL597484 |  |
IC50 | = | 8.0 | nM | 317.69 | O=P(O)(O)COc1ccc(Cl)c2c1-c1ncsc1C2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL1173572 |  |
IC50 | = | 8.0 | nM | 495.54 | CCOC(=O)[C@H](C)NP(=O)(COc1ccc(C)c2c1-c1ncsc1C2)N[C@@H](C)C(=O)OCC | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL597282 |  |
IC50 | = | 8.0 | nM | 297.27 | Cc1ccc(OCP(=O)(O)O)c2c1Cc1scnc1-2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL597691 |  |
IC50 | = | 9.0 | nM | 360.33 | O=P(O)(O)COc1ccc(-c2cccnc2)c2c1-c1ncsc1C2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL605956 |  |
IC50 | = | 9.0 | nM | 360.33 | O=P(O)(O)COc1ccc(-c2ccncc2)c2c1-c1ncsc1C2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL457189 |  |
IC50 | = | 9.0 | nM | 565.5 | O=C(NCCCCCCCNC(=O)NS(=O)(=O)c1cccc(Cl)c1)NS(=O)(=O)c1cccc(Cl)c1 | Homo sapiens | CHEMBL974537 | assay format |
| CHEMBL592639 |  |
IC50 | = | 9.0 | nM | 319.22 | O=P(O)(O)COc1cc(F)c(F)c2c1-c1ncsc1C2 | Homo sapiens | CHEMBL1074153 | assay format |
| CHEMBL1172936 |  |
IC50 | = | 10.0 | nM | 481.51 | CCOC(=O)CNP(=O)(COc1cc(C)c(C)c2c1-c1ncsc1C2)NCC(=O)OCC | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL1172935 |  |
IC50 | = | 10.0 | nM | 537.62 | Cc1cc(OCP(=O)(N[C@@H](C)C(=O)OC(C)C)N[C@@H](C)C(=O)OC(C)C)c2c(c1C)Cc1scnc1-2 | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL1650184 |  |
IC50 | = | 10.0 | nM | 328.33 | Nc1nc(-c2ccc(P(=O)(O)O)o2)c(C2CCCCC2)s1 | Homo sapiens | CHEMBL1657811 | assay format |
| CHEMBL1096789 |  |
IC50 | = | 10.0 | nM | 509.57 | CCOC(=O)[C@H](C)NP(=O)(COc1cc(C)c(C)c2c1-c1ncsc1C2)N[C@@H](C)C(=O)OCC | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL259771 |  |
IC50 | = | 10.0 | nM | 500.56 | CCOC(=O)[C@H](C)NP(=O)(N[C@@H](C)C(=O)OCC)c1ccc(-c2nc(N)sc2CC(C)C)o1 | Homo sapiens | CHEMBL1175836 | single protein format |
| CHEMBL609616 |  |
IC50 | = | 10.0 | nM | 311.3 | Cc1cc(OCP(=O)(O)O)c2c(c1C)Cc1scnc1-2 | Homo sapiens | CHEMBL1074153 | assay format |