P08913 | ADA2A_HUMAN | Alpha-2A adrenergic receptor (ADRA2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 65~441 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL157138 |  |
IC50 | = | 0.31 | nM | 338.46 | CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL513389 |  |
IC50 | = | 0.5 | nM | 277.41 | Cc1ccc(OCC(O)C(C)NC(C)C)c2c1CCC2 | Homo sapiens | CHEMBL2395774 | single protein format |
| CHEMBL1732 |  |
IC50 | = | 1.032 | nM | 583.69 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL442 |  |
IC50 | = | 2.123 | nM | 581.67 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL537669 |  |
IC50 | = | 3.67 | nM | 390.91 | COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O.Cl | Homo sapiens | CHEMBL1046745 | cell-based format |
| CHEMBL194173 |  |
IC50 | = | 5.6 | nM | 588.45 | CN(C)c1nc(NCC2CCN(S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 | Homo sapiens | CHEMBL831429 | cell-based format |
| CHEMBL597 |  |
IC50 | = | 6.0 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL15245 |  |
IC50 | = | 6.151 | nM | 354.45 | COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL1385840 |  |
IC50 | = | 6.296 | nM | 561.68 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL1403281 |  |
IC50 | = | 7.946 | nM | 575.71 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL85 |  |
IC50 | = | 9.674 | nM | 410.49 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL367355 |  |
IC50 | = | 9.9 | nM | 580.45 | CN(C)c1nc(NCC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 | Homo sapiens | CHEMBL831139 | cell-based format |
| CHEMBL762 |  |
IC50 | = | 23.0 | nM | 260.38 | Cc1cc(C(C)(C)C)c(O)c(C)c1CC1=NCCN1 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL360117 |  |
IC50 | = | 31.0 | nM | 566.47 | CN(C)c1nc(NCC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 | Homo sapiens | CHEMBL831139 | cell-based format |
| CHEMBL50588 |  |
IC50 | = | 38.0 | nM | 480.65 | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL420 |  |
IC50 | = | 41.0 | nM | 231.09 | N=C(N)N/N=C/c1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL6437 |  |
IC50 | = | 43.0 | nM | 264.37 | CN1CCN2c3ccccc3Cc3ccccc3C2C1 | Homo sapiens | CHEMBL1909088 | cell membrane format |
| CHEMBL182235 |  |
IC50 | = | 44.0 | nM | 580.49 | CN(Cc1ccc(Br)cc1OC(F)(F)F)CC1CCC(CNc2nc(N(C)C)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL831139 | cell-based format |
| CHEMBL193771 |  |
IC50 | = | 47.0 | nM | 588.45 | CN(C)c1nc(NC2CCC(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 | Homo sapiens | CHEMBL831429 | cell-based format |
| CHEMBL362400 |  |
IC50 | = | 47.0 | nM | 458.39 | CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)nc2ccccc12 | Homo sapiens | CHEMBL831139 | cell-based format |