P08908 | 5HT1A_HUMAN | 5-hydroxytryptamine receptor 1A (HTR1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 53~400 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL439849 |  |
IC50 | = | 0.11 | nM | 441.54 | N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1 | Homo sapiens | CHEMBL4840631 | single protein format |
| CHEMBL4864918 |  |
IC50 | = | 0.14 | nM | 491.6 | N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccc6occc6c5=O)cc4)CC3)c2c1 | Homo sapiens | CHEMBL4840631 | single protein format |
| CHEMBL60447 |  |
IC50 | = | 0.2 | nM | 369.49 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4O)CC3)ccc21 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL64878 |  |
IC50 | = | 0.2 | nM | 397.54 | COc1ccccc1N1CCN(CCCCc2ccc3nc(O)sc3c2)CC1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL304438 |  |
IC50 | = | 0.2 | nM | 381.48 | COc1ccccc1N1CCN(CCc2ccc3c(c2)OCC(=O)N3C)CC1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL60885 |  |
IC50 | = | 0.3 | nM | 369.49 | COc1ccccc1N1CCN(CCc2ccc3nc(O)sc3c2)CC1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL4128926 |  |
IC50 | = | 0.43 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121498 | single protein format |
| CHEMBL4867414 |  |
IC50 | = | 0.5 | nM | 502.62 | N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(-n5ccc6ncccc6c5=O)cc4)CC3)c2c1 | Homo sapiens | CHEMBL4840631 | single protein format |
| CHEMBL64610 |  |
IC50 | = | 0.6 | nM | 447.5 | CN1C(=O)COc2cc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL4476621 |  |
IC50 | = | 0.6 | nM | 356.23 | O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O | Homo sapiens | CHEMBL4383311 | single protein format |
| CHEMBL56 |  |
IC50 | = | 0.66 | nM | 247.38 | CCCN(CCC)C1CCc2cccc(O)c2C1 | Homo sapiens | CHEMBL871862 | single protein format |
| CHEMBL64167 |  |
IC50 | = | 0.7 | nM | 353.49 | Cn1c(=O)sc2cc(CCN3CCN(c4ccccc4)CC3)ccc21 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL61869 |  |
IC50 | = | 0.7 | nM | 355.46 | Oc1nc2ccc(CCN3CCN(c4ccccc4O)CC3)cc2s1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL60047 |  |
IC50 | = | 0.7 | nM | 419.45 | CN1C(=O)COc2cc(CCN3CCN(c4cccc(C(F)(F)F)c4)CC3)ccc21 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL423361 |  |
IC50 | = | 0.77 | nM | 408.55 | O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1 | Homo sapiens | CHEMBL1776882 | cell-based format |
| CHEMBL61819 |  |
IC50 | = | 0.8 | nM | 411.57 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)sc(=O)n3C)CC1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL59823 |  |
IC50 | = | 0.8 | nM | 409.53 | COc1ccccc1N1CCN(CCCCc2ccc3c(c2)OCC(=O)N3C)CC1 | Homo sapiens | CHEMBL615581 | assay format |
| CHEMBL431367 |  |
IC50 | = | 0.8 | nM | 346.47 | Oc1ccc2[nH]cc(CCCCN3CC=C(c4ccccc4)CC3)c2c1 | Homo sapiens | CHEMBL1069075 | single protein format |
| CHEMBL31354 |  |
IC50 | = | 0.91 | nM | 422.57 | COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 | Homo sapiens | CHEMBL1776882 | cell-based format |
| CHEMBL537403 |  |
IC50 | = | 0.91 | nM | 531.96 | COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1.Cl.Cl.Cl | Homo sapiens | CHEMBL1912164 | cell-based format |