P08684 | CP3A4_HUMAN | Cytochrome P450 3A4 (CYP3A4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 39~493 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3125537 |  |
IC50 | = | 0.0962 | nM | 580.57 | CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3705484 | single protein format |
| CHEMBL3407554 |  |
IC50 | = | 0.102 | nM | 598.56 | CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(=O)O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL3705484 | single protein format |
| CHEMBL3236364 |  |
IC50 | = | 1.83 | nM | 579.59 | CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1C(=O)[C@@](C)(CC(N)=O)C[C@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3705484 | single protein format |
| CHEMBL104 |  |
IC50 | = | 16.0 | nM | 344.85 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL808 |  |
IC50 | = | 50.0 | nM | 381.69 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL157101 |  |
IC50 | = | 57.0 | nM | 531.44 | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | Homo sapiens | CHEMBL1177588 | microsome format |
| CHEMBL1221 |  |
IC50 | = | 70.0 | nM | 397.76 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL75 |  |
IC50 | = | 77.0 | nM | 531.44 | CC(=O)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 | Homo sapiens | CHEMBL5041175 | microsome format |
| CHEMBL1262 |  |
IC50 | = | 90.0 | nM | 429.13 | Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL389433 |  |
IC50 | < | 100.0 | nM | 308.77 | Clc1cccc(C(c2ccc3[nH]cnc3c2)n2ccnc2)c1 | Homo sapiens | CHEMBL3887280 | single protein format |
| CHEMBL91 |  |
IC50 | = | 100.0 | nM | 416.13 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL1437764 |  |
IC50 | = | 100.0 | nM | 292.77 | CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1 | Homo sapiens | CHEMBL3887280 | single protein format |
| CHEMBL3645217 |  |
IC50 | = | 221.0 | nM | 427.46 | O=C(O)CCC(=O)Nc1ccc(-c2c(O)ccc3cc(-c4cccc(O)c4)ccc23)cc1 | Homo sapiens | CHEMBL3707848 | single protein format |
| CHEMBL2103760 |  |
IC50 | = | 240.0 | nM | 478.66 | CC[C@]1(C)C[C@@H](OC(=O)CSc2nnc(N)[nH]2)[C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@H]32)[C@@H](C)[C@@H]1O | Homo sapiens | CHEMBL4818570 | microsome format |
| CHEMBL1969102 |  |
IC50 | = | 300.0 | nM | 440.53 | Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 | Homo sapiens | CHEMBL3705428 | assay format |
| CHEMBL1729 |  |
IC50 | = | 300.0 | nM | 465.95 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC | Homo sapiens | CHEMBL1909138 | cell-based format |
| CHEMBL3952468 |  |
IC50 | = | 300.0 | nM | 346.86 | ClC1CC=CC=C1C(c1ccccc1)(c1ccccc1)n1ccnc1 | Homo sapiens | CHEMBL3887294 | tissue-based format |
| CHEMBL3967139 |  |
IC50 | = | 300.0 | nM | 439.52 | Cc1ccc(-n2nccn2)c(C(=O)N2CCOC[C@H]2Cc2cccc(-c3ccncc3)c2)c1 | Homo sapiens | CHEMBL3887326 | tissue-based format |
| CHEMBL3109542 |  |
IC50 | = | 449.0 | nM | 393.49 | COc1ccc(C2(c3ccc(OC)cc3)NC(=N)N(C3CCCCC3)C2=O)cc1 | Homo sapiens | CHEMBL3888557 | single protein format |
| CHEMBL1172847 |  |
IC50 | = | 464.0 | nM | 317.39 | CC(C)=C(c1ccncc1)c1ccc(-c2ccc(O)c(O)c2)cc1 | Homo sapiens | CHEMBL1177588 | microsome format |