P08648 | ITA5_HUMAN | Integrin alpha-5 (ITGA5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01839 | FG-GAP - FG-GAP repeat | 326~368 | |
| PF01839 | FG-GAP - FG-GAP repeat | 392~428 | |
| PF08441 | Integrin_A_Ig_1 - Integrin alpha Ig-like domain 1 | 490~644 | |
| PF20805 | Integrin_A_Ig_2 - Integrin alpha Ig-like domain 2 | 645~786 | |
| PF20806 | Integrin_A_Ig_3 - Integrin alpha Ig-like domain 3 | 792~988 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Integrin_alpha2_1st ]
[ Domain: "7-bladed" // FG-GAP_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL595105 |  |
IC50 | < | 100.0 | nM | 514.67 | Cc1ccnc(NCC2CCN(c3ccc(CC(NC(=O)c4c(C)cc(C)cc4C)C(=O)O)cc3)CC2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681919 |  |
IC50 | < | 100.0 | nM | 526.68 | Cc1cc(C)c(C(=O)NC(Cc2ccc(N3CCC(c4ccc5c(n4)NCCC5)CC3)cc2)C(=O)O)c(C)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681920 |  |
IC50 | < | 100.0 | nM | 484.64 | CC1(C(=O)NC(CC2CCN(C(=O)CCc3ccc4c(n3)NCCC4)CC2)C(=O)O)CCCCC1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681921 |  |
IC50 | < | 100.0 | nM | 492.66 | Cc1ccnc(NCC2CCN(c3ccc(CC(NC(=O)C4(C)CCCCC4)C(=O)O)cc3)CC2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681917 |  |
IC50 | < | 100.0 | nM | 514.63 | Cc1ccnc(NCC2CC(=O)N(c3ccc(CC(NC(=O)c4c(C)cc(C)cc4C)C(=O)O)cc3)C2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL590354 |  |
IC50 | < | 100.0 | nM | 518.63 | CCc1cc(F)cc(C)c1C(=O)NC(Cc1ccc(N2CCC(CNc3ccccn3)CC2)cc1)C(=O)O | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL591543 |  |
IC50 | < | 100.0 | nM | 530.67 | COc1ccnc(NCC2CCN(c3ccc(CC(NC(=O)c4c(C)cc(C)cc4C)C(=O)O)cc3)CC2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681922 |  |
IC50 | < | 100.0 | nM | 472.59 | Cc1ccnc(NCC2CCN(c3ccc(CC(NC(=O)c4ccccc4)C(=O)O)cc3)CC2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681923 |  |
IC50 | < | 100.0 | nM | 528.7 | Cc1ccnc(NCC2CCN(c3ccc(CC(NC(=O)C(c4ccccc4)C(C)C)C(=O)O)cc3)CC2)c1 | Homo sapiens | CHEMBL3705530 | single protein format |
| CHEMBL3681924 |  |
IC50 | < | 100.0 | nM | 508.66 | CCCNC(=O)NCC1CCN(c2ccc(CC(NC(=O)c3c(C)cc(C)cc3C)C(=O)O)cc2)CC1 | Homo sapiens | CHEMBL3705530 | single protein format |