P08311 | CATG_HUMAN | Cathepsin G (CTSG)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 21~238 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL47394 |  |
IC50 | = | 0.39 | nM | 266.3 | O=C1N(Cc2ccccc2)C(=O)N1Cc1ccccc1 | Homo sapiens | CHEMBL661876 | single protein format |
| CHEMBL1807526 |  |
IC50 | = | 2.1 | nM | 366.44 | Cc1cccc2scc(Cn3c(=O)n(CCC(=O)O)c4ccccc43)c12 | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL296771 |  |
IC50 | = | 2.3 | nM | 266.3 | Cc1ccc(N2C(=O)N(c3ccc(C)cc3)C2=O)cc1 | Homo sapiens | CHEMBL661876 | single protein format |
| CHEMBL1807531 |  |
IC50 | = | 4.8 | nM | 363.42 | Cc1cccc2c1c(Cn1c(=O)n(CCC(=O)O)c3ccccc31)cn2C | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL335675 |  |
IC50 | = | 6.4 | nM | 536.71 | CCCCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCCC)NC(=O)c1ccccc1 | Homo sapiens | CHEMBL661887 | single protein format |
| CHEMBL1807638 |  |
IC50 | = | 7.0 | nM | 391.47 | Cc1cc(Cn2c(=O)n(CCC(=O)O)c3ccccc32)c2c(c1)c(C)c(C)n2C | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL108294 |  |
IC50 | = | 8.4 | nM | 505.66 | CCCCCCC(NC(=O)c1ccc(C#N)cc1)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC | Homo sapiens | CHEMBL661877 | single protein format |
| CHEMBL1807538 |  |
IC50 | = | 8.8 | nM | 363.42 | Cc1cn(C)c2c(Cn3c(=O)n(CCC(=O)O)c4ccccc43)cccc12 | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL1807535 |  |
IC50 | = | 9.5 | nM | 381.46 | Cc1cc(C)c2c(Cn3c(=O)n(CCC(=O)O)c4ccccc43)nsc2c1 | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL270515 |  |
IC50 | = | 13.7 | nM | 413.28 | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)c1cccc(-c2ccccc2)n1)[C@@H](C)O)B(O)O | Homo sapiens | CHEMBL1274448 | single protein format |
| CHEMBL436591 |  |
IC50 | = | 21.0 | nM | 564.77 | CCCC(=O)NC(CCc1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCc1ccccc1)NC(=O)CCC | Homo sapiens | CHEMBL661887 | single protein format |
| CHEMBL1807640 |  |
IC50 | = | 22.0 | nM | 411.89 | Cc1c(C)n(C)c2c(Cn3c(=O)n(CCC(=O)O)c4ccccc43)cc(Cl)cc12 | Homo sapiens | CHEMBL1811508 | single protein format |
| CHEMBL424453 |  |
IC50 | = | 48.0 | nM | 564.77 | CCCCCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCCCC)NC(=O)c1ccccc1 | Homo sapiens | CHEMBL661887 | single protein format |
| CHEMBL1807642 |  |
IC50 | = | 52.0 | nM | 396.54 | Cc1cccc2scc(Cn3c(SCCCC(=O)O)nc4ccccc43)c12 | Homo sapiens | CHEMBL2383100 | single protein format |
| CHEMBL131704 |  |
IC50 | = | 75.0 | nM | 508.66 | CCCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCC)NC(=O)c1ccccc1 | Homo sapiens | CHEMBL661887 | single protein format |
| CHEMBL111705 |  |
IC50 | = | 77.0 | nM | 519.69 | CCCCCCC(NC(=O)c1ccc(C#N)cc1)C(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)C | Homo sapiens | CHEMBL661877 | single protein format |
| CHEMBL135080 |  |
IC50 | = | 80.0 | nM | 592.82 | CCCCCCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CCCCCC)NC(=O)c1ccccc1 | Homo sapiens | CHEMBL661887 | single protein format |
| CHEMBL515494 |  |
IC50 | = | 90.0 | nM | 443.42 | N#C[C@@]1(NC(=O)C(N)Cc2sccc2F)C[C@@H]1c1ccccc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1007397 | cell-based format |
| CHEMBL516292 |  |
IC50 | = | 150.0 | nM | 425.43 | N#C[C@@]1(NC(=O)[C@@H](N)Cc2cccs2)C[C@@H]1c1ccccc1.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1007397 | cell-based format |
| CHEMBL134068 |  |
IC50 | = | 160.0 | nM | 480.61 | CCC(NC(=O)c1ccccc1)C(C)(C)C(=O)OC(=O)C(C)(C)C(CC)NC(=O)c1ccccc1 | Homo sapiens | CHEMBL661887 | single protein format |