P08236 | BGLR_HUMAN | Beta-glucuronidase (GUSB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00703 | Glyco_hydro_2 - Glycosyl hydrolases family 2 | 226~327 | |
| PF02836 | Glyco_hydro_2_C - Glycosyl hydrolases family 2, TIM barrel domain | 329~630 | |
| PF02837 | Glyco_hydro_2_N - Glycosyl hydrolases family 2, sugar binding domain | 39~224 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Glyco_hydro_2_N ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Glyco_hydro_2 ]
[ Domain: "TIM barrels" // Glyco_hydro_2_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3980115 |  |
IC50 | = | 1.17 | nM | 411.54 | C1CCc2c(c(N3CCOCC3)nc3sc4c(N5CCNCC5)nnnc4c23)C1 | Homo sapiens | CHEMBL3888431 | cell-based format |
| CHEMBL5409470 |  |
IC50 | = | 8.0 | nM | 410.43 | O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)c2nc(CCc3cccc(Oc4ccccc4)c3)cn21 | Homo sapiens | CHEMBL5372317 | single protein format |
| CHEMBL5273557 |  |
IC50 | = | 9.75 | nM | 386.33 | O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)c2nc(CCc3ccc(C(F)(F)F)cc3)cn21 | Homo sapiens | CHEMBL5225196 | single protein format |
| CHEMBL4635113 |  |
IC50 | = | 20.0 | nM | 514.07 | O=S(=O)(NCc1cccc2ccccc12)c1cc(Cl)c(Oc2cccc(N3CCNCC3)c2)s1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4642327 |  |
IC50 | = | 100.0 | nM | 533.63 | O=C(NNC(=S)Nc1ccccc1F)c1ccc(C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1 | Homo sapiens | CHEMBL4616981 | single protein format |
| CHEMBL4642420 |  |
IC50 | = | 118.0 | nM | 379.46 | Cc1cc(C)c2[nH]c(=O)c(CN(CCO)C(=O)Nc3ccccc3C)cc2c1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4632976 |  |
IC50 | = | 120.0 | nM | 583.64 | O=C(NNC(=S)Nc1ccc(C(F)(F)F)cc1)c1ccc(C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1 | Homo sapiens | CHEMBL4616981 | single protein format |
| CHEMBL4641808 |  |
IC50 | = | 142.0 | nM | 397.45 | Cc1cc(C)c2[nH]c(=O)c(CN(CCO)C(=O)Nc3ccc(F)cc3C)cc2c1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4643914 |  |
IC50 | = | 200.0 | nM | 584.53 | O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccc(C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1 | Homo sapiens | CHEMBL4616981 | single protein format |
| CHEMBL2335167 |  |
IC50 | = | 230.6 | nM | 302.45 | Cc1nc(N2CCNCC2)c2c3c(sc2n1)CC(C)CC3 | Homo sapiens | CHEMBL3888431 | cell-based format |
| CHEMBL3903683 |  |
IC50 | = | 282.5 | nM | 425.55 | CCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1 | Homo sapiens | CHEMBL3888431 | cell-based format |
| CHEMBL4640688 |  |
IC50 | = | 347.0 | nM | 444.33 | Cc1cc(C)c2[nH]c(=O)c(CN(CCO)C(=O)Nc3ccccc3Br)cc2c1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL1370584 |  |
IC50 | = | 350.0 | nM | 309.46 | CCN(CC)C(=O)C1=C(C)N=C(S)NC1c1cccs1 | Homo sapiens | CHEMBL4628377 | single protein format |
| CHEMBL1236932 |  |
IC50 | = | 369.3 | nM | 411.53 | COc1cccc(NC(=S)N(CCO)Cc2cc3cc(C)c(C)cc3[nH]c2=O)c1 | Homo sapiens | CHEMBL3888431 | cell-based format |
| CHEMBL4641364 |  |
IC50 | = | 370.0 | nM | 411.53 | COc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4642057 |  |
IC50 | = | 468.0 | nM | 407.51 | Cc1cc(C)c2[nH]c(=O)c(CN(CCO)C(=O)Nc3ccccc3C(C)C)cc2c1 | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4644690 |  |
IC50 | = | 500.0 | nM | 309.35 | Oc1cccc(-c2nnc(-c3ccc4[nH]ccc4c3)s2)c1O | Homo sapiens | CHEMBL4616962 | single protein format |
| CHEMBL4634834 |  |
IC50 | = | 500.0 | nM | 550.09 | O=C(NNC(=S)Nc1ccccc1Cl)c1ccc(C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1 | Homo sapiens | CHEMBL4616981 | single protein format |
| CHEMBL4641089 |  |
IC50 | = | 500.0 | nM | 345.74 | O=C(N/N=C/c1cc(O)c(O)cc1O)c1cc2cc(Cl)ccc2[nH]1 | Homo sapiens | CHEMBL4616981 | single protein format |
| CHEMBL4634026 |  |
IC50 | = | 540.0 | nM | 304.46 | Cc1nc2c(c(N3CCNCC3)n1)C1CCC(C)CC1S2 | Homo sapiens | CHEMBL4616962 | single protein format |