P08069 | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00757 | Furin-like - Furin-like cysteine rich region | 176~333 | |
| PF01030 | Recep_L_domain - Receptor L domain | 51~160 | |
| PF01030 | Recep_L_domain - Receptor L domain | 352~462 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 999~1265 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Growth factor receptor domain" // Furin-like_5 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3950012 |  |
IC50 | = | 0.05 | nM | 589.75 | COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3905758 |  |
IC50 | = | 0.05 | nM | 549.69 | CN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)n2)CC1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3955626 |  |
IC50 | = | 0.08 | nM | 591.72 | COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3928243 |  |
IC50 | = | 0.08 | nM | 548.7 | Cn1cc(-c2cccc(Cc3c4c(nn3C)CCc3cnc(Nc5ccn(CCCN6CCCC6)n5)nc3-4)c2)cn1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3896205 |  |
IC50 | = | 0.09 | nM | 563.71 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCN(C)CC5)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3969930 |  |
IC50 | = | 0.09 | nM | 591.77 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCC(N(C)C)CC5)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3979509 |  |
IC50 | = | 0.09 | nM | 575.72 | CCN1CCN(c2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)c(OC)c2)CC1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3985408 |  |
IC50 | = | 0.1 | nM | 593.74 | COCCN1CCN(CCn2ccc(Nc3ncc4c(n3)-c3c(nn(C)c3-c3ccc(-c5cnn(C)c5)cc3)CC4)n2)CC1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3916799 |  |
IC50 | = | 0.1 | nM | 509.62 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2Cc2cccc(-c4cnn(CCOC)c4)c2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3892425 |  |
IC50 | = | 0.1 | nM | 508.59 | CN(C)C(=O)Cn1cc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(C)c4)cc2)CC3)cn1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3893323 |  |
IC50 | = | 0.1 | nM | 549.69 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCNCC5)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3823268 |  |
IC50 | = | 0.11 | nM | 445.85 | COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 | Homo sapiens | CHEMBL3824710 | single protein format |
| CHEMBL3986353 |  |
IC50 | = | 0.11 | nM | 534.67 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCCC5)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3961098 |  |
IC50 | = | 0.11 | nM | 538.66 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCNCCOC)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3921486 |  |
IC50 | = | 0.12 | nM | 522.66 | CC(C)n1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3947924 |  |
IC50 | = | 0.13 | nM | 591.72 | COc1cc(C(=O)NCCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3911964 |  |
IC50 | = | 0.13 | nM | 538.66 | COCCn1cc(-c2ccc(-c3c4c(nn3C)CCc3cnc(Nc5ccn(CCN(C)C)n5)nc3-4)cc2)cn1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3965426 |  |
IC50 | = | 0.13 | nM | 508.63 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN(C)C)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3942607 |  |
IC50 | = | 0.13 | nM | 577.69 | COc1cc(C(=O)NCCN(C)C)ccc1Nc1ncc2c(n1)-c1c(nn(C)c1-c1ccc(-c3cnn(C)c3)cc1)CC2 | Homo sapiens | CHEMBL3887328 | single protein format |
| CHEMBL3907737 |  |
IC50 | = | 0.13 | nM | 593.74 | CCn1ccc(Nc2ncc3c(n2)-c2c(nn(C)c2-c2ccc(-c4cnn(CCN5CCN(CCO)CC5)c4)cc2)CC3)n1 | Homo sapiens | CHEMBL3887328 | single protein format |