P07949 | RET_HUMAN | Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00028 | Cadherin - Cadherin domain | 173~260 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 725~1005 | |
| PF17756 | RET_CLD1 - RET Cadherin like domain 1 | 29~153 | |
| PF17812 | RET_CLD3 - RET Cadherin like domain 3 | 265~379 | |
| PF17813 | RET_CLD4 - RET Cadherin like domain 4 | 405~506 | |
| PF22540 | RET_CRD - RET, Cysteine Rich Domain | 518~620 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Cadherin_4 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // EUF07683 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Cadherin_repeat_like ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Cadherin ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5429146 |  |
IC50 | = | 0.0 | nM | 463.54 | COCCCn1nc(-c2ccc(CC(=O)Nc3cc(C(C)(C)C)on3)cc2)c2c(N)ncnc21 | Homo sapiens | CHEMBL5380966 | single protein format |
| CHEMBL4067871 |  |
IC50 | = | 0.04 | nM | 467.96 | OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 | Homo sapiens | CHEMBL4018630 | single protein format |
| CHEMBL4218013 |  |
IC50 | = | 0.1 | nM | 561.58 | CCOc1cc(-c2ccc(NC(=O)Nc3ccc(CN4CCN(CC)CC4)c(C(F)(F)F)c3)c(F)c2)c[nH]c1=O | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL1784637 |  |
IC50 | = | 0.2 | nM | 582.63 | CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C | Homo sapiens | CHEMBL1785336 | single protein format |
| CHEMBL4218563 |  |
IC50 | = | 0.2 | nM | 505.51 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)N)c(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL4062877 |  |
IC50 | = | 0.2 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 | Homo sapiens | CHEMBL4018630 | single protein format |
| CHEMBL4872605 |  |
IC50 | = | 0.36 | nM | 544.64 | Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN([C@@H](C)c4ccc(-n5cc(F)cn5)nc4)C3=O)CC2)n1 | Homo sapiens | CHEMBL4836452 | single protein format |
| CHEMBL4212513 |  |
IC50 | = | 0.4 | nM | 516.45 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(-c3nnc(C)o3)cc(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL4075917 |  |
IC50 | = | 0.4 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 | Homo sapiens | CHEMBL4018630 | single protein format |
| CHEMBL4205243 |  |
IC50 | = | 0.4 | nM | 520.52 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL4218127 |  |
IC50 | = | 0.4 | nM | 506.5 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)O)c(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL3355010 |  |
IC50 | = | 0.4 | nM | 467.42 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(C(C)(C)C(F)(F)F)no2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL3355009 |  |
IC50 | = | 0.4 | nM | 467.42 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(C(C)(C)C(F)(F)F)on2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL5171764 |  |
IC50 | = | 0.4 | nM | 533.61 | COC1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CCC(c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 | Homo sapiens | CHEMBL5152017 | single protein format |
| CHEMBL3775169 |  |
IC50 | = | 0.41 | nM | 333.29 | COc1cc2ncnc(Nc3cc(O)c(F)cc3F)c2cc1OC | Homo sapiens | CHEMBL3778237 | assay format |
| CHEMBL388978 |  |
IC50 | = | 0.46 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL973459 | single protein format |
| CHEMBL4203429 |  |
IC50 | = | 0.6 | nM | 582.62 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CS(C)(=O)=O)c(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL4870957 |  |
IC50 | = | 0.68 | nM | 545.63 | Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN([C@@H](C)c4cnc(-n5cc(F)cn5)cn4)C3=O)CC2)n1 | Homo sapiens | CHEMBL4836452 | single protein format |
| CHEMBL4214146 |  |
IC50 | = | 0.7 | nM | 487.45 | CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C(C)C#N)c(C(F)(F)F)c2)c(F)c1 | Homo sapiens | CHEMBL4199570 | single protein format |
| CHEMBL4205803 |  |
IC50 | = | 0.7 | nM | 512.58 | CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4ccc(NC)nc4)cc3)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL4199570 | single protein format |