P07948 | LYN_HUMAN | Tyrosine-protein kinase Lyn (LYN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 129~211 | |
| PF00018 | SH3_1 - SH3 domain | 69~115 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 247~496 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1784637 |  |
IC50 | < | 0.15 | nM | 582.63 | CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C | Homo sapiens | CHEMBL1785333 | single protein format |
| CHEMBL1171837 |  |
IC50 | = | 0.24 | nM | 532.57 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL3998349 | single protein format |
| CHEMBL475584 |  |
IC50 | = | 0.4 | nM | 443.55 | COc1cccc(-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c3ncnc(N)c23)c1 | Homo sapiens | CHEMBL4274924 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.49 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL973448 | single protein format |
| CHEMBL272888 |  |
IC50 | = | 0.9 | nM | 589.62 | Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 | Homo sapiens | CHEMBL951120 | single protein format |
| CHEMBL249317 |  |
IC50 | = | 1.0 | nM | 371.42 | Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 | Homo sapiens | CHEMBL923139 | single protein format |
| CHEMBL5416410 |  |
IC50 | = | 1.2 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL4412237 | single protein format |
| CHEMBL3647967 |  |
IC50 | = | 1.2 | nM | 454.53 | C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 | Homo sapiens | CHEMBL3887542 | single protein format |
| CHEMBL281957 |  |
IC50 | = | 2.0 | nM | 484.43 | CCN(CC)C/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C | Homo sapiens | CHEMBL769383 | single protein format |
| CHEMBL4436086 |  |
IC50 | = | 2.118 | nM | 462.3 | Oc1cccc(Nc2nc(/C=C/c3cc4c(cc3Br)OCO4)nc3ccccc23)c1 | Homo sapiens | CHEMBL4412237 | single protein format |
| CHEMBL2336005 |  |
IC50 | = | 2.3 | nM | 417.53 | Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 | Homo sapiens | CHEMBL3707752 | cell membrane format |
| CHEMBL249097 |  |
IC50 | = | 3.0 | nM | 335.37 | Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(C(N)=O)c2)n1 | Homo sapiens | CHEMBL923139 | single protein format |
| CHEMBL383010 |  |
IC50 | = | 3.1 | nM | 572.51 | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(Br)c2)cc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL892515 | cell-based format |
| CHEMBL2347053 |  |
IC50 | = | 4.0 | nM | 332.32 | O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] | Homo sapiens | CHEMBL2350678 | single protein format |
| CHEMBL364623 |  |
IC50 | = | 4.0 | nM | 373.87 | Cc1cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)nc(C)n1 | Homo sapiens | CHEMBL912342 | single protein format |
| CHEMBL4798527 |  |
IC50 | = | 4.0 | nM | 548.57 | Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 | Homo sapiens | CHEMBL4766145 | single protein format |
| CHEMBL203343 |  |
IC50 | = | 4.8 | nM | 561.61 | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 | Homo sapiens | CHEMBL892515 | cell-based format |
| CHEMBL1086731 |  |
IC50 | = | 5.0 | nM | 497.63 | Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1Nc1nc2ccccc2n1-c1cc(N)ncn1 | Homo sapiens | CHEMBL1113979 | cell-based format |
| CHEMBL4467948 |  |
IC50 | = | 7.0 | nM | 476.37 | Cc1ccc(C(=O)Nc2ccc(Cl)cc2Cl)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N | Homo sapiens | CHEMBL4839599 | single protein format |
| CHEMBL1163016 |  |
IC50 | = | 7.0 | nM | 499.6 | CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] | Homo sapiens | CHEMBL1046247 | single protein format |